State Street’s Septerna Inc SEPN Stock Holding History

State Street’s Portfolio SEPN Stock Details SEPN Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2026 Q2	$21.9M	Buy	652,630 +21,183	+3%	+$601K	﹤0.01%	2308
2026 Q1	$15.2M	Buy	631,447 +91,419	+17%	+$2.4M	﹤0.01%	2385
2025 Q4	$15.1M	Buy	540,028 +121,068	+29%	+$2.89M	﹤0.01%	2407
2025 Q3	$7.88M	Buy	418,960 +48,968	+13%	+$643K	﹤0.01%	2768
2025 Q2	$3.91M	Buy	369,992 +25,388	+7%	+$209K	﹤0.01%	3048
2025 Q1	$2M	Buy	344,604 +71,828	+26%	+$820K	﹤0.01%	3248
2024 Q4	$6.25M	Buy	+272,776	New	+$6.45M	﹤0.01%	2866

Other funds holding SEPN

RCM

RA Capital Management Boston, Massachusetts $11.5B AUM 168.77% 1-Year Est. Return

TGV

TRV GP V Boston, Massachusetts $498M AUM 267.53% 1-Year Est. Return

DCM

Driehaus Capital Management Chicago, Illinois $17.3B AUM 211.34% 1-Year Est. Return

TGV

TRV GP VI Boston, Massachusetts $232M AUM 247.08% 1-Year Est. Return

Samsara BioCapital Palo Alto, California $1.22B AUM 242.83% 1-Year Est. Return

Goldman Sachs New York $1.15T AUM 47.82% 1-Year Est. Return

BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return

Siren LLC Greenwich, Connecticut $4.94B AUM 244.43% 1-Year Est. Return

ACA

Avoro Capital Advisors New York $11.1B AUM 207.82% 1-Year Est. Return

Jupiter Topco New York $245B AUM

State Street's SEPN Position: Q2 2026 in Review

State Street increased its Septerna Inc (SEPN) stake by 3.4% in Q2 2026, buying an estimated $601K and bringing the position to 652,630 shares worth $21.9M. The position accounts for ﹤0.01% of the portfolio, ranked #2308.

State Street first reported a position in SEPN in Q4 2024 and has held it in 7 quarters since. 154 funds tracked by Wall St. Rank hold SEPN as of Q2 2026.

State Street held 652,630 shares of Septerna Inc worth $21.9M as of Q2 2026.
State Street bought 21,183 Septerna Inc shares in Q2 2026, an estimated $601K.
Septerna Inc made up ﹤0.01% of State Street's portfolio in Q2 2026, its #2308 holding.
State Street first reported a position in Septerna Inc in Q4 2024 and has held it in 7 quarters since.
154 funds tracked by Wall St. Rank held Septerna Inc as of Q2 2026.

Based on State Street's 13F filing for Q2 2026, filed 7 Aug 2026.