State Street
SEPN

State Street’s Septerna Inc SEPN Stock Holding History

State Street’s Portfolio SEPN Stock Details SEPN Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$15.2M Buy
631,447
+91,419
+17% +$2.4M ﹤0.01% 2385
2025
Q4 		$15.1M Buy
540,028
+121,068
+29% +$2.89M ﹤0.01% 2407
2025
Q3 		$7.88M Buy
418,960
+48,968
+13% +$643K ﹤0.01% 2768
2025
Q2 		$3.91M Buy
369,992
+25,388
+7% +$209K ﹤0.01% 3048
2025
Q1 		$2M Buy
344,604
+71,828
+26% +$820K ﹤0.01% 3248
2024
Q4 		$6.25M Buy
+272,776
New +$6.45M ﹤0.01% 2866

Other funds holding SEPN

RCM
RA Capital Management Boston, Massachusetts $9.44B AUM 157.3% 1-Year Est. Return
TGV
TRV GP V Boston, Massachusetts $401M AUM 284.76% 1-Year Est. Return
DCM
Driehaus Capital Management Chicago, Illinois $13.6B AUM 173.98% 1-Year Est. Return
TGV
TRV GP VI Boston, Massachusetts $136M AUM 328.39% 1-Year Est. Return
SB
Samsara BioCapital Palo Alto, California $1.03B AUM 214.94% 1-Year Est. Return
Goldman Sachs
Goldman Sachs New York $871B AUM 31.28% 1-Year Est. Return
SL
Siren LLC Greenwich, Connecticut $3.61B AUM 203.3% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
BI
BVF Inc San Francisco, California $3.14B AUM 249.53% 1-Year Est. Return
ACA
Avoro Capital Advisors New York $10.2B AUM 149.19% 1-Year Est. Return

State Street's SEPN Position: Q1 2026 in Review

State Street increased its Septerna Inc (SEPN) stake by 17% in Q1 2026, buying an estimated $2.4M and bringing the position to 631,447 shares worth $15.2M. The position accounts for ﹤0.01% of the portfolio, ranked #2385.

State Street first reported a position in SEPN in Q4 2024 and has held it in 6 quarters since. 124 funds tracked by Wall St. Rank hold SEPN as of Q1 2026.

  • State Street held 631,447 shares of Septerna Inc worth $15.2M as of Q1 2026.
  • State Street bought 91,419 Septerna Inc shares in Q1 2026, an estimated $2.4M.
  • Septerna Inc made up ﹤0.01% of State Street's portfolio in Q1 2026, its #2385 holding.
  • State Street first reported a position in Septerna Inc in Q4 2024 and has held it in 6 quarters since.
  • 124 funds tracked by Wall St. Rank held Septerna Inc as of Q1 2026.

Based on State Street's 13F filing for Q1 2026, filed 15 May 2026.