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SEPN

Septerna Inc
SEPN

71 hedge funds and large institutions have $1.01B invested in Septerna Inc in 2024 Q4 according to their latest regulatory filings, with 71 funds opening new positions, increasing their positions, reducing their positions, and closing their positions.

New
Increased
Maintained
Reduced
Closed

99.39% more ownership

Funds ownership: 0% → 99.39% (+99%)

Holders
71
Holders Change
+71
Holders Change %
–
% of All Funds
0.94%
Holding in Top 10
5
Holding in Top 10 Change
+5
Holding in Top 10 Change %
% of All Funds
0.07%
New
71
Increased
–
Reduced
–
Closed
–
Calls
–
Puts
–
Net Calls
–
Net Calls Change
–

Top Buyers

Rank Fund Capital Flow
1
RCM
RA Capital Management
Massachusetts
+$165M
2
SB
Samsara BioCapital
California
+$65.5M
3
DCM
Driehaus Capital Management
Illinois
+$61.2M
4
BI
BVF Inc
California
+$58M
5
SL
Siren LLC
Connecticut
+$52.1M

Top Sellers

No sellers this quarter
Name Holding Trade Value Shares
Change 		Change in
Stake
State Street
26
State Street
Massachusetts
$6.25M +$6.45M +272,776 New
SCM
27
Sio Capital Management
New York
$6.22M +$6.42M +271,687 New
ACH
28
ArrowMark Colorado Holdings
Colorado
$3.39M +$3.5M +147,886 New
Northern Trust
29
Northern Trust
Illinois
$3.38M +$3.49M +147,776 New
Charles Schwab
30
Charles Schwab
California
$3.2M +$3.3M +139,616 New
LGM
31
Logos Global Management
California
$3.07M +$3.17M +134,202 New
UBS Group
32
UBS Group
Switzerland
$2.48M +$2.56M +108,453 New
Universal-Beteiligungs- und Servicegesellschaft
33
Universal-Beteiligungs- und Servicegesellschaft
Germany
$2.35M +$2.43M +102,749 New
Bank of America
34
Bank of America
North Carolina
$1.8M +$1.86M +78,744 New
TD Asset Management
35
TD Asset Management
Ontario, Canada
$1.59M +$1.64M +69,460 New
Morgan Stanley
36
Morgan Stanley
New York
$960K +$991K +41,911 New
Bank of New York Mellon
37
Bank of New York Mellon
New York
$872K +$901K +38,093 New
JP Morgan Chase
38
JP Morgan Chase
New York
$871K +$899K +38,015 New
Alyeska Investment Group
39
Alyeska Investment Group
Illinois
$802K +$828K +35,000 New
Barclays
40
Barclays
United Kingdom
$659K +$681K +28,785 New
Jane Street
41
Jane Street
New York
$600K +$620K +26,208 New
N
42
Nuveen
North Carolina
$549K +$567K +23,961 New
Verition Fund Management
43
Verition Fund Management
Connecticut
$520K +$537K +22,695 New
Manulife (Manufacturers Life Insurance)
44
Manulife (Manufacturers Life Insurance)
Ontario, Canada
$506K +$522K +22,095 New
LC
45
Lindbrook Capital
California
$481K +$497K +21,000 New
Walleye Capital
46
Walleye Capital
New York
$463K +$478K +20,204 New
RhumbLine Advisers
47
RhumbLine Advisers
Massachusetts
$458K +$473K +19,995 New
M&T Bank
48
M&T Bank
New York
$376K +$388K +16,394 New
Citigroup
49
Citigroup
New York
$335K +$346K +14,633 New
Invesco
50
Invesco
Georgia
$278K +$287K +12,154 New
1
2
3

SEPN Hedge Fund Activity: Q4 2024 in Review

71 of the 7,593 institutional investors tracked by Wall St. Rank reported a position in Septerna Inc (SEPN) for Q4 2024, worth a combined $1.01B.

Buyers outnumbered sellers: 71 funds opened new SEPN positions and 0 closed out — a net gain of 71 holders — while 0 added to existing stakes and 0 trimmed.

The largest buyer was RA Capital Management, opening a new position worth an estimated $165M.

  • 71 institutional investors held Septerna Inc (SEPN) as of Q4 2024, up from 0 in Q3 2024.
  • Funds reported $1.01B of Septerna Inc stock for Q4 2024.
  • 71 funds opened new Septerna Inc positions in Q4 2024 and 0 closed out, a net change of +71 holders.
  • The largest Septerna Inc buyer in Q4 2024 was RA Capital Management, an estimated $165M added.

Based on aggregated 13F filings for Q4 2024.