Jane Street
SEPN

Jane Street’s Septerna Inc SEPN Stock Holding History

Jane Street’s Portfolio SEPN Stock Details SEPN Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$1.53M Buy
+45,552
New +$1.29M ﹤0.01% 5661
2026
Q1 		– Sell
-44,070
Closed -$1.23M – 13330
2025
Q4 		$1.23M Buy
+44,070
New +$1.05M ﹤0.01% 5732
2025
Q1 		– Sell
-26,208
Closed -$299K – 10976
2024
Q4 		$600K Buy
+26,208
New +$620K ﹤0.01% 6385

Other funds holding SEPN

RCM
RA Capital Management Boston, Massachusetts $11.5B AUM 168.77% 1-Year Est. Return
TGV
TRV GP V Boston, Massachusetts $498M AUM 267.53% 1-Year Est. Return
DCM
Driehaus Capital Management Chicago, Illinois $17.3B AUM 211.34% 1-Year Est. Return
TGV
TRV GP VI Boston, Massachusetts $232M AUM 247.08% 1-Year Est. Return
SB
Samsara BioCapital Palo Alto, California $1.22B AUM 242.83% 1-Year Est. Return
Goldman Sachs
Goldman Sachs New York $1.15T AUM 47.82% 1-Year Est. Return
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
SL
Siren LLC Greenwich, Connecticut $4.94B AUM 244.43% 1-Year Est. Return
ACA
Avoro Capital Advisors New York $11.1B AUM 207.82% 1-Year Est. Return
JT
Jupiter Topco New York $245B AUM

Jane Street's SEPN Position: Q2 2026 in Review

Jane Street opened a new position in Septerna Inc (SEPN) in Q2 2026: 45,552 shares worth $1.53M. The stake represents ﹤0.01% of the portfolio and ranks #5661 among its holdings. This is a return to the name: Jane Street previously reported a position in SEPN as recently as Q4 2025.

Jane Street first reported a position in SEPN in Q4 2024 and has held it in 3 quarters since. 153 funds tracked by Wall St. Rank hold SEPN as of Q2 2026.

  • Jane Street held 45,552 shares of Septerna Inc worth $1.53M as of Q2 2026.
  • Septerna Inc was a new Jane Street position in Q2 2026.
  • Septerna Inc made up ﹤0.01% of Jane Street's portfolio in Q2 2026, its #5661 holding.
  • Jane Street first reported a position in Septerna Inc in Q4 2024 and has held it in 3 quarters since.
  • 153 funds tracked by Wall St. Rank held Septerna Inc as of Q2 2026.

Based on Jane Street's 13F filing for Q2 2026, filed 14 Aug 2026.