Jane Street’s Septerna Inc SEPN Stock Holding History

Jane Street’s Portfolio SEPN Stock Details SEPN Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2026 Q1	–	Sell	-80,200	Closed	-$2.24M	–	13331
2025 Q4	$2.24M	Sell	80,200 -272,200	-77%	-$6.5M	﹤0.01%	4605
2025 Q3	$6.63M	Sell	352,400 -95,900	-21%	-$1.26M	﹤0.01%	2988
2025 Q2	$4.74M	Buy	448,300 +404,300	+919%	+$3.33M	﹤0.01%	3076
2025 Q1	$255K	Buy	+44,000	New	+$502K	﹤0.01%	8079

Other funds holding SEPN

RCM

RA Capital Management Boston, Massachusetts $9.44B AUM 157.3% 1-Year Est. Return

TGV

TRV GP V Boston, Massachusetts $401M AUM 284.76% 1-Year Est. Return

DCM

Driehaus Capital Management Chicago, Illinois $13.6B AUM 173.98% 1-Year Est. Return

TGV

TRV GP VI Boston, Massachusetts $136M AUM 328.39% 1-Year Est. Return

Samsara BioCapital Palo Alto, California $1.03B AUM 214.94% 1-Year Est. Return

Goldman Sachs New York $871B AUM 31.28% 1-Year Est. Return

Siren LLC Greenwich, Connecticut $3.61B AUM 203.3% 1-Year Est. Return

BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return

BVF Inc San Francisco, California $3.14B AUM 249.53% 1-Year Est. Return

ACA

Avoro Capital Advisors New York $10.2B AUM 149.19% 1-Year Est. Return

Jane Street's SEPN Position: Q1 2026 in Review

Jane Street sold out of Septerna Inc (SEPN) in Q1 2026, closing a stake of 44,070 shares — an estimated $1.23M sold.

Jane Street first reported a position in SEPN in Q4 2024 and held it in 2 quarters. The position peaked at $1.23M in Q4 2025. 124 funds tracked by Wall St. Rank hold SEPN as of Q1 2026.

Jane Street reported no remaining Septerna Inc position as of Q1 2026 after selling out during the quarter.
Jane Street sold 44,070 Septerna Inc shares in Q1 2026, an estimated $1.23M.
Jane Street first reported a position in Septerna Inc in Q4 2024 and held it in 2 quarters.
Jane Street's Septerna Inc position peaked at $1.23M in Q4 2025.
124 funds tracked by Wall St. Rank held Septerna Inc as of Q1 2026.

Based on Jane Street's 13F filing for Q1 2026, filed 12 May 2026.