BBA

Baker Bros. Advisors Portfolio holdings

AUM $10.3B
This Quarter Return
+6.01%
1 Year Return
+63.34%
3 Year Return
+231.6%
5 Year Return
+293.68%
10 Year Return
+1,612.7%
AUM
$9.04B
AUM Growth
+$9.04B
Cap. Flow
-$178M
Cap. Flow %
-1.97%
Top 10 Hldgs %
81.82%
Holding
99
New
4
Increased
11
Reduced
16
Closed
9

Top Buys

1
IMVT icon
Immunovant
IMVT
$64.1M
2
INSM icon
Insmed
INSM
$28.5M
3
IMCR icon
Immunocore
IMCR
$24M
4
PCVX icon
Vaxcyte
PCVX
$22.4M
5
CELC icon
Celcuity
CELC
$16M

Top Sells

1
ONC
BeOne Medicines Ltd. American Depositary Shares
ONC
$199M
2
KRYS icon
Krystal Biotech
KRYS
$26.6M
3
RYTM icon
Rhythm Pharmaceuticals
RYTM
$25.4M
4
CRSP icon
CRISPR Therapeutics
CRSP
$22.3M
5
AKRO icon
Akero Therapeutics
AKRO
$22.2M

Sector Composition

1 Healthcare 98.88%
Name Market Value Portfolio Weight Shares or Principal Shares
Change % 		Capital Flow
XNCR icon
51
Xencor
XNCR
$583M
$7.13M 0.08%
670,431
– –
DYN icon
52
Dyne Therapeutics
DYN
$1.89B
$7.03M 0.08%
672,096
– –
KALA icon
53
KALA BIO
KALA
$94.4M
$6.89M 0.08%
1,201,894
– –
DSGN icon
54
Design Therapeutics
DSGN
$331M
$6.73M 0.07%
1,743,725
– –
GPCR icon
55
Structure Therapeutics
GPCR
$1.18B
$6.26M 0.07%
361,565
– –
TSHA icon
56
Taysha Gene Therapies
TSHA
$783M
$5.57M 0.06%
4,004,756
– –
RGLS
57
DELISTED
Regulus Therapeutics
RGLS
$4.71M 0.05%
+2,694,044
New +$4.71M
IGMS
58
DELISTED
IGM Biosciences
IGMS
$4.71M 0.05%
4,095,257
+953
+0% +$1.1K
NTLA icon
59
Intellia Therapeutics
NTLA
$1.25B
$4.58M 0.05%
644,116
– –
CLDX icon
60
Celldex Therapeutics
CLDX
$1.55B
$4.49M 0.05%
247,644
– –
SION
61
Sionna Therapeutics, Inc. Common Stock
SION
$1.14B
$4.18M 0.05%
+400,000
New +$4.18M
BNTX icon
62
BioNTech
BNTX
$24.1B
$4.1M 0.05%
45,031
– –
TCRX icon
63
TScan Therapeutics
TCRX
$99.3M
$3.84M 0.04%
2,784,792
– –
IRON icon
64
Disc Medicine
IRON
$2.15B
$3.82M 0.04%
77,050
– –
VIR icon
65
Vir Biotechnology
VIR
$735M
$3.52M 0.04%
542,539
-542,000
-50% -$3.51M
SANA icon
66
Sana Biotechnology
SANA
$729M
$3.41M 0.04%
2,030,949
-350,000
-15% -$588K
SGMT icon
67
Sagimet Biosciences
SGMT
$241M
$3.11M 0.03%
952,996
– –
RLAY icon
68
Relay Therapeutics
RLAY
$676M
$3.04M 0.03%
1,160,117
– –
WVE icon
69
Wave Life Sciences
WVE
$1.23B
$2.78M 0.03%
344,063
– –
FATE icon
70
Fate Therapeutics
FATE
$115M
$2.57M 0.03%
3,258,402
– –
SKYE icon
71
Skye Bioscience
SKYE
$104M
$2.31M 0.03%
1,450,638
– –
TARA icon
72
Protara Therapeutics
TARA
$125M
$2.29M 0.03%
536,832
– –
ELVN icon
73
Enliven Therapeutics
ELVN
$1.22B
$2.26M 0.03%
114,833
– –
CTNM
74
Contineum Therapeutics
CTNM
$298M
$2.18M 0.02%
312,500
– –
PRME icon
75
Prime Medicine
PRME
$583M
$2.05M 0.02%
1,028,466
– –
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3
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