UPB

Upstream Bio, Inc. Common Stock

78 hedge funds and large institutions have $261M invested in Upstream Bio, Inc. Common Stock in 2025 Q1 according to their latest regulatory filings, with 24 funds opening new positions, 11 increasing their positions, 25 reducing their positions, and 15 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
78
Holders Change
+8
Holders Change %
+11.43%
% of All Funds
1.06%
Holding in Top 10
4
Holding in Top 10 Change
-2
Holding in Top 10 Change %
-33.33%
% of All Funds
0.05%
New
24
Increased
11
Reduced
25
Closed
15
Calls
Puts
Net Calls
Net Calls Change
Name Holding Trade Value Shares
Change
Shares
Change %
Northern Trust
26
Northern Trust
Illinois
$843K -$36.4K -5,950 -4%
Charles Schwab
27
Charles Schwab
California
$809K -$19.3K -3,150 -2%
UBS Group
28
UBS Group
Switzerland
$805K -$183K -29,961 -19%
VCIM
29
Velan Capital Investment Management
Georgia
$655K +$655K +107,000 New
Alyeska Investment Group
30
Alyeska Investment Group
Illinois
$520K
Millennium Management
31
Millennium Management
New York
$378K +$378K +61,796 New
EC
32
EcoR1 Capital
California
$367K
Morgan Stanley
33
Morgan Stanley
New York
$315K +$50.4K +8,228 +19%
AA
34
ALPS Advisors
Colorado
$239K -$26.1K -4,261 -10%
Bank of New York Mellon
35
Bank of New York Mellon
New York
$226K -$6 -1 -0%
Goldman Sachs
36
Goldman Sachs
New York
$202K -$70.6K -11,535 -26%
Barclays
37
Barclays
United Kingdom
$153K -$12.4K -2,024 -7%
NL
38
Nuveen LLC
North Carolina
$138K +$138K +22,586 New
Two Sigma Investments
39
Two Sigma Investments
New York
$133K +$133K +21,789 New
Susquehanna International Group
40
Susquehanna International Group
Pennsylvania
$130K +$130K +21,264 New
AQR Capital Management
41
AQR Capital Management
Connecticut
$115K +$115K +18,822 New
Citigroup
42
Citigroup
New York
$111K -$51K -8,326 -31%
Invesco
43
Invesco
Georgia
$93.7K -$1.76K -287 -2%
IIM
44
INTECH Investment Management
Florida
$93.5K +$93.5K +15,285 New
QCM
45
Quantinno Capital Management
New York
$93.2K +$93.2K +15,225 New
JPMorgan Chase & Co
46
JPMorgan Chase & Co
New York
$93K -$199K -32,598 -68%
Deutsche Bank
47
Deutsche Bank
Germany
$93K +$2.09K +341 +2%
ACM
48
ADAR1 Capital Management
Texas
$91.8K +$91.8K +15,000 New
RhumbLine Advisers
49
RhumbLine Advisers
Massachusetts
$81.6K -$20.8K -3,394 -20%
XT
50
XTX Topco
Cayman Islands
$77.9K +$77.9K +12,731 New