Two Sigma Investments
UPB

Two Sigma Investments’s Upstream Bio Inc UPB Stock Holding History

Two Sigma Investments’s Portfolio UPB Stock Details UPB Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		– Sell
-10,500
Closed -$285K – 4999
2025
Q4 		$285K Hold
10,500
– – ﹤0.01% 3601
2025
Q3 		$198K Buy
+10,500
New +$163K ﹤0.01% 3380
2025
Q2 		– Sell
-21,789
Closed -$133K – 3629
2025
Q1 		$133K Buy
+21,789
New +$208K ﹤0.01% 2921

Other funds holding UPB

Fidelity Investments
Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return
O
OrbiMed New York $5.05B AUM 125.28% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
DC
Decheng Capital Menlo Park, California $661M AUM 299.97% 1-Year Est. Return
ES
Enavate Sciences Menlo Park, California $352M AUM 220.14% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
YIH
Y-Intercept (HK) Hong Kong $5.05B AUM 17.89% 1-Year Est. Return
Federated Hermes
Federated Hermes Pittsburgh, Pennsylvania $61.5B AUM 30.7% 1-Year Est. Return
Geode Capital Management
Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return
Millennium Management
Millennium Management New York $240B AUM 35.51% 1-Year Est. Return

Two Sigma Investments's UPB Position: Q1 2026 in Review

Two Sigma Investments sold out of Upstream Bio Inc (UPB) in Q1 2026, closing a stake of 10,500 shares — an estimated $285K sold.

Two Sigma Investments first reported a position in UPB in Q1 2025 and held it in 3 quarters. The position peaked at $285K in Q4 2025. 140 funds tracked by Wall St. Rank hold UPB as of Q1 2026.

  • Two Sigma Investments reported no remaining Upstream Bio Inc position as of Q1 2026 after selling out during the quarter.
  • Two Sigma Investments sold 10,500 Upstream Bio Inc shares in Q1 2026, an estimated $285K.
  • Two Sigma Investments first reported a position in Upstream Bio Inc in Q1 2025 and held it in 3 quarters.
  • Two Sigma Investments's Upstream Bio Inc position peaked at $285K in Q4 2025.
  • 140 funds tracked by Wall St. Rank held Upstream Bio Inc as of Q1 2026.

Based on Two Sigma Investments's 13F filing for Q1 2026, filed 15 May 2026.