Two Sigma Investments’s Upstream Bio, Inc. Common Stock UPB Stock Holding History

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Shares Change %	Capital Flow	Portfolio Weight	Portfolio Position
2025 Q2	–	Sell	-21,789	Closed	-$133K	–	3569
2025 Q1	$133K	Buy	+21,789	New	+$133K	﹤0.01%	2861