Two Sigma Investments
UPB

Two Sigma Investments’s Upstream Bio Inc UPB Stock Holding History

Two Sigma Investments’s Portfolio UPB Stock Details UPB Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$293K Buy
+42,325
New +$355K ﹤0.01% 4540
2026
Q1 		– Sell
-10,500
Closed -$285K – 4999
2025
Q4 		$285K Hold
10,500
– – ﹤0.01% 3601
2025
Q3 		$198K Buy
+10,500
New +$163K ﹤0.01% 3380
2025
Q2 		– Sell
-21,789
Closed -$133K – 3629
2025
Q1 		$133K Buy
+21,789
New +$208K ﹤0.01% 2921

Other funds holding UPB

Fidelity Investments
Fidelity Investments Boston, Massachusetts $2.3T AUM 54.33% 1-Year Est. Return
O
OrbiMed New York $5.4B AUM 163.13% 1-Year Est. Return
Norges Bank
Norges Bank Oslo, Norway $1T AUM
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
DC
Decheng Capital Menlo Park, California $732M AUM 275.56% 1-Year Est. Return
ES
Enavate Sciences Menlo Park, California $345M AUM 134.64% 1-Year Est. Return
Vanguard Capital Management
Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM
Millennium Management
Millennium Management New York $276B AUM 44.8% 1-Year Est. Return
D.E. Shaw & Co
D.E. Shaw & Co New York $210B AUM 57.28% 1-Year Est. Return
JP Morgan Chase
JP Morgan Chase New York $1.81T AUM 41.13% 1-Year Est. Return

Two Sigma Investments's UPB Position: Q2 2026 in Review

Two Sigma Investments opened a new position in Upstream Bio Inc (UPB) in Q2 2026: 42,325 shares worth $293K. The stake represents ﹤0.01% of the portfolio and ranks #4540 among its holdings. This is a return to the name: Two Sigma Investments previously reported a position in UPB as recently as Q4 2025.

Two Sigma Investments first reported a position in UPB in Q1 2025 and has held it in 4 quarters since. 148 funds tracked by Wall St. Rank hold UPB as of Q2 2026.

  • Two Sigma Investments held 42,325 shares of Upstream Bio Inc worth $293K as of Q2 2026.
  • Upstream Bio Inc was a new Two Sigma Investments position in Q2 2026.
  • Upstream Bio Inc made up ﹤0.01% of Two Sigma Investments's portfolio in Q2 2026, its #4540 holding.
  • Two Sigma Investments first reported a position in Upstream Bio Inc in Q1 2025 and has held it in 4 quarters since.
  • 148 funds tracked by Wall St. Rank held Upstream Bio Inc as of Q2 2026.

Based on Two Sigma Investments's 13F filing for Q2 2026, filed 14 Aug 2026.