Goldman Sachs
UPB

Goldman Sachs’s Upstream Bio Inc UPB Stock Holding History

Goldman Sachs’s Portfolio UPB Stock Details UPB Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$2.85M Sell
316,587
-16,894
-5% -$304K ﹤0.01% 4212
2025
Q4 		$9.05M Buy
333,481
+110,267
+49% +$2.74M ﹤0.01% 3188
2025
Q3 		$4.2M Buy
+223,214
New +$3.47M ﹤0.01% 3803
2025
Q2 		– Sell
-32,955
Closed -$202K – 6534
2025
Q1 		$202K Sell
32,955
-11,535
-26% -$110K ﹤0.01% 5640
2024
Q4 		$731K Buy
+44,490
New +$993K ﹤0.01% 5033

Other funds holding UPB

Fidelity Investments
Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return
O
OrbiMed New York $5.05B AUM 125.28% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
DC
Decheng Capital Menlo Park, California $661M AUM 299.97% 1-Year Est. Return
ES
Enavate Sciences Menlo Park, California $352M AUM 220.14% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
YIH
Y-Intercept (HK) Hong Kong $5.05B AUM 17.89% 1-Year Est. Return
Federated Hermes
Federated Hermes Pittsburgh, Pennsylvania $61.5B AUM 30.7% 1-Year Est. Return
Geode Capital Management
Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return
Millennium Management
Millennium Management New York $240B AUM 35.51% 1-Year Est. Return

Goldman Sachs's UPB Position: Q1 2026 in Review

Goldman Sachs reduced its Upstream Bio Inc (UPB) stake by 5.1% in Q1 2026, selling an estimated $304K and leaving 316,587 shares worth $2.85M. The position accounts for ﹤0.01% of the portfolio, ranked #4212.

Goldman Sachs first reported a position in UPB in Q4 2024 and has held it in 5 quarters since. The position peaked at $9.05M in Q4 2025. 140 funds tracked by Wall St. Rank hold UPB as of Q1 2026.

  • Goldman Sachs held 316,587 shares of Upstream Bio Inc worth $2.85M as of Q1 2026.
  • Goldman Sachs sold 16,894 Upstream Bio Inc shares in Q1 2026, an estimated $304K.
  • Upstream Bio Inc made up ﹤0.01% of Goldman Sachs's portfolio in Q1 2026, its #4212 holding.
  • Goldman Sachs first reported a position in Upstream Bio Inc in Q4 2024 and has held it in 5 quarters since.
  • Goldman Sachs's Upstream Bio Inc position peaked at $9.05M in Q4 2025.
  • 140 funds tracked by Wall St. Rank held Upstream Bio Inc as of Q1 2026.

Based on Goldman Sachs's 13F filing for Q1 2026, filed 15 May 2026.