UPB

Upstream Bio, Inc. Common Stock
UPB

Overview Fund Activity

81 hedge funds and large institutions have $530M invested in Upstream Bio, Inc. Common Stock in 2025 Q2 according to their latest regulatory filings, with 14 funds opening new positions, 40 increasing their positions, 13 reducing their positions, and 10 closing their positions.

Holders
81
Holders Change
+3
Holders Change %
+3.85%
% of All Funds
1.09%
Holding in Top 10
4
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.05%
New
14
Increased
40
Reduced
13
Closed
10
Calls
–
Puts
–
Net Calls
–
Net Calls Change
–

Top Buyers

1
Vanguard Group
1
Vanguard Group
Pennsylvania
$23.8M
2
Norges Bank
2
Norges Bank
Norway
$10.6M
3
BlackRock
3
BlackRock
New York
$23M
4
Fidelity Investments
4
Fidelity Investments
Massachusetts
$87.1M
5
PHP
5
Parkman Healthcare Partners
Connecticut
$7.86M

Top Sellers

1
AllianceBernstein
1
AllianceBernstein
Tennessee
$270K
2
DTC
2
Deep Track Capital
Connecticut
$15.8M
3
SB
3
Samsara BioCapital
California
$15.8M
4
Wellington Management Group
4
Wellington Management Group
Massachusetts
$13.5M
5
Millennium Management
5
Millennium Management
New York
$0
Name Market Value Shares Shares
Change 		Shares
Change %
Fidelity Investments
1
Fidelity Investments
Massachusetts
$87.1M 7,936,880 +681,021 +9%
O
2
OrbiMed
New York
$62.5M 5,693,589 – –
AS
3
Altshuler Shaham
Israel
$37.3M 3,394,441 +159,148 +5%
DC
4
Decheng Capital
California
$36.1M 3,285,293 – –
TCM
5
TCG Crossover Management
California
$30.8M 2,801,763 – –
ES
6
Enavate Sciences
California
$27M 2,459,703 – –
BCLSI
7
Bain Capital Life Sciences Investors
Massachusetts
$26.8M 2,439,538 +144,216 +6%
VA
8
VR Adviser
New York
$25.2M 2,295,319 – –
Vanguard Group
9
Vanguard Group
Pennsylvania
$23.8M 2,170,833 +1,263,807 +139%
BlackRock
10
BlackRock
New York
$23M 2,096,506 +910,738 +77%
OFM
11
Omega Fund Management
Massachusetts
$22.4M 2,036,293 – –
SB
12
Samsara BioCapital
California
$15.8M 1,443,231 -623,915 -30%
DTC
13
Deep Track Capital
Connecticut
$15.8M 1,442,767 -856,800 -37%
Wellington Management Group
14
Wellington Management Group
Massachusetts
$13.5M 1,225,295 -88,162 -7%
Norges Bank
15
Norges Bank
Norway
$10.6M 969,916 +969,916 New
SL
16
Siren LLC
Connecticut
$8.66M 788,450 – –
PHP
17
Parkman Healthcare Partners
Connecticut
$7.86M 715,504 +481,941 +206%
Geode Capital Management
18
Geode Capital Management
Massachusetts
$7.1M 646,635 +235,958 +57%
NCM
19
Nantahala Capital Management
Connecticut
$6.53M 594,971 – –
WP
20
Woodline Partners
California
$6.13M 558,252 +1,189 +0.2%
State Street
21
State Street
Massachusetts
$5.29M 481,375 +185,788 +63%
SSA
22
Schonfeld Strategic Advisors
New York
$4.02M 365,790 +187,806 +106%
GPP
23
Great Point Partners
Connecticut
$3.29M 300,000 – –
Marshall Wace
24
Marshall Wace
United Kingdom
$3.19M 290,526 -14,437 -5%
UBS Group
25
UBS Group
Switzerland
$2.56M 232,887 +101,336 +77%
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