UPB

Upstream Bio, Inc. Common Stock
UPB

Overview Fund Activity

70 hedge funds and large institutions have $690M invested in Upstream Bio, Inc. Common Stock in 2024 Q4 according to their latest regulatory filings, with 70 funds opening new positions, increasing their positions, reducing their positions, and closing their positions.

Holders
70
Holders Change
+70
Holders Change %
–
% of All Funds
0.93%
Holding in Top 10
6
Holding in Top 10 Change
+6
Holding in Top 10 Change %
%
% of All Funds
0.08%
New
70
Increased
–
Reduced
–
Closed
–
Calls
–
Puts
–
Net Calls
–
Net Calls Change
–

Top Buyers

1
Fidelity Investments
1
Fidelity Investments
Massachusetts
$118M
2
O
2
OrbiMed
New York
$93.6M
3
DC
3
Decheng Capital
California
$54M
4
TCM
4
TCG Crossover Management
California
$44.9M
5
BCLSI
5
Bain Capital Life Sciences Investors
Massachusetts
$37.7M

Top Sellers

No sellers this quarter
Name Market Value Shares Shares
Change 		Shares
Change %
Fidelity Investments
1
Fidelity Investments
Massachusetts
$118M 7,176,187 +7,176,187 New
O
2
OrbiMed
New York
$93.6M 5,693,589 +5,693,589 New
DC
3
Decheng Capital
California
$54M 3,285,293 +3,285,293 New
TCM
4
TCG Crossover Management
California
$44.9M 2,801,763 +2,801,763 New
ES
5
Enavate Sciences
California
$40.4M 2,459,703 +2,459,703 New
BCLSI
6
Bain Capital Life Sciences Investors
Massachusetts
$37.7M 2,295,322 +2,295,322 New
VA
7
VR Adviser
New York
$37.7M 2,295,319 +2,295,319 New
SB
8
Samsara BioCapital
California
$36.4M 2,217,146 +2,217,146 New
OFM
9
Omega Fund Management
Massachusetts
$33.5M 2,036,293 +2,036,293 New
Wellington Management Group
10
Wellington Management Group
Massachusetts
$25.6M 1,583,154 +1,583,154 New
BlackRock
11
BlackRock
New York
$18.4M 1,117,800 +1,117,800 New
AllianceBernstein
12
AllianceBernstein
Tennessee
$18.3M 1,111,337 +1,111,337 New
DTC
13
Deep Track Capital
Connecticut
$16.4M 1,000,000 +1,000,000 New
Norges Bank
14
Norges Bank
Norway
$16.4M 1,000,000 +1,000,000 New
Vanguard Group
15
Vanguard Group
Pennsylvania
$15M 915,021 +915,021 New
SL
16
Siren LLC
Connecticut
$13.2M 800,000 +800,000 New
NCM
17
Nantahala Capital Management
Connecticut
$9.86M 600,000 +600,000 New
WP
18
Woodline Partners
California
$8.66M 526,511 +526,511 New
Geode Capital Management
19
Geode Capital Management
Massachusetts
$5.97M 363,269 +363,269 New
Balyasny Asset Management
20
Balyasny Asset Management
Illinois
$4.95M 301,152 +301,152 New
GPP
21
Great Point Partners
Connecticut
$4.93M 300,000 +300,000 New
Marshall Wace
22
Marshall Wace
United Kingdom
$4.78M 290,734 +290,734 New
State Street
23
State Street
Massachusetts
$4.06M 247,187 +247,187 New
LCM
24
Lynx1 Capital Management
Puerto Rico
$3.95M 240,042 +240,042 New
Citadel Advisors
25
Citadel Advisors
Florida
$2.96M 180,000 +180,000 New
1
2 3