Fidelity Investments
UPB

Fidelity Investments’s Upstream Bio Inc UPB Stock Holding History

Fidelity Investments’s Portfolio UPB Stock Details UPB Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$56.5M Buy
8,162,897
+61,334
+0.8% +$514K ﹤0.01% 1464
2026
Q1 		$72.9M Buy
8,101,563
+583,361
+8% +$10.5M ﹤0.01% 1290
2025
Q4 		$204M Sell
7,518,202
-568,211
-7% -$14.1M 0.01% 854
2025
Q3 		$152M Buy
8,086,413
+149,533
+2% +$2.32M 0.01% 975
2025
Q2 		$87.1M Buy
7,936,880
+681,021
+9% +$6.29M ﹤0.01% 1178
2025
Q1 		$44.4M Buy
7,255,859
+79,672
+1% +$761K ﹤0.01% 1400
2024
Q4 		$118M Buy
+7,176,187
New +$160M 0.01% 1048

Other funds holding UPB

O
OrbiMed New York $5.4B AUM 163.13% 1-Year Est. Return
Norges Bank
Norges Bank Oslo, Norway $1T AUM
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
DC
Decheng Capital Menlo Park, California $732M AUM 275.56% 1-Year Est. Return
ES
Enavate Sciences Menlo Park, California $345M AUM 134.64% 1-Year Est. Return
Vanguard Capital Management
Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM
Millennium Management
Millennium Management New York $276B AUM 44.8% 1-Year Est. Return
D.E. Shaw & Co
D.E. Shaw & Co New York $210B AUM 57.28% 1-Year Est. Return
JP Morgan Chase
JP Morgan Chase New York $1.81T AUM 41.13% 1-Year Est. Return
Qube Research & Technologies (QRT)
Qube Research & Technologies (QRT) London, United Kingdom $108B AUM 37.29% 1-Year Est. Return

Fidelity Investments's UPB Position: Q2 2026 in Review

Fidelity Investments increased its Upstream Bio Inc (UPB) stake by 0.76% in Q2 2026, buying an estimated $514K and bringing the position to 8,162,897 shares worth $56.5M. The position accounts for ﹤0.01% of the portfolio, ranked #1464.

Fidelity Investments first reported a position in UPB in Q4 2024 and has held it in 7 quarters since. The position peaked at $204M in Q4 2025. 149 funds tracked by Wall St. Rank hold UPB as of Q2 2026.

  • Fidelity Investments held 8,162,897 shares of Upstream Bio Inc worth $56.5M as of Q2 2026.
  • Fidelity Investments bought 61,334 Upstream Bio Inc shares in Q2 2026, an estimated $514K.
  • Upstream Bio Inc made up ﹤0.01% of Fidelity Investments's portfolio in Q2 2026, its #1464 holding.
  • Fidelity Investments first reported a position in Upstream Bio Inc in Q4 2024 and has held it in 7 quarters since.
  • Fidelity Investments's Upstream Bio Inc position peaked at $204M in Q4 2025.
  • 149 funds tracked by Wall St. Rank held Upstream Bio Inc as of Q2 2026.

Based on Fidelity Investments's 13F filing for Q2 2026, filed 13 Aug 2026.