Fidelity Investments
UPB

Fidelity Investments’s Upstream Bio Inc UPB Stock Holding History

Fidelity Investments’s Portfolio UPB Stock Details UPB Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$72.9M Buy
8,101,563
+583,361
+8% +$10.5M ﹤0.01% 1290
2025
Q4 		$204M Sell
7,518,202
-568,211
-7% -$14.1M 0.01% 854
2025
Q3 		$152M Buy
8,086,413
+149,533
+2% +$2.32M 0.01% 975
2025
Q2 		$87.1M Buy
7,936,880
+681,021
+9% +$6.29M ﹤0.01% 1178
2025
Q1 		$44.4M Buy
7,255,859
+79,672
+1% +$761K ﹤0.01% 1400
2024
Q4 		$118M Buy
+7,176,187
New +$160M 0.01% 1048

Other funds holding UPB

O
OrbiMed New York $5.05B AUM 125.28% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
DC
Decheng Capital Menlo Park, California $661M AUM 299.97% 1-Year Est. Return
ES
Enavate Sciences Menlo Park, California $352M AUM 220.14% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
YIH
Y-Intercept (HK) Hong Kong $5.05B AUM 17.89% 1-Year Est. Return
Federated Hermes
Federated Hermes Pittsburgh, Pennsylvania $61.5B AUM 30.7% 1-Year Est. Return
Geode Capital Management
Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return
Millennium Management
Millennium Management New York $240B AUM 35.51% 1-Year Est. Return
SAM
SEB Asset Management Stockholm $23.4B AUM

Fidelity Investments's UPB Position: Q1 2026 in Review

Fidelity Investments increased its Upstream Bio Inc (UPB) stake by 7.8% in Q1 2026, buying an estimated $10.5M and bringing the position to 8,101,563 shares worth $72.9M. The position accounts for ﹤0.01% of the portfolio, ranked #1290.

Fidelity Investments first reported a position in UPB in Q4 2024 and has held it in 6 quarters since. The position peaked at $204M in Q4 2025. 140 funds tracked by Wall St. Rank hold UPB as of Q1 2026.

  • Fidelity Investments held 8,101,563 shares of Upstream Bio Inc worth $72.9M as of Q1 2026.
  • Fidelity Investments bought 583,361 Upstream Bio Inc shares in Q1 2026, an estimated $10.5M.
  • Upstream Bio Inc made up ﹤0.01% of Fidelity Investments's portfolio in Q1 2026, its #1290 holding.
  • Fidelity Investments first reported a position in Upstream Bio Inc in Q4 2024 and has held it in 6 quarters since.
  • Fidelity Investments's Upstream Bio Inc position peaked at $204M in Q4 2025.
  • 140 funds tracked by Wall St. Rank held Upstream Bio Inc as of Q1 2026.

Based on Fidelity Investments's 13F filing for Q1 2026, filed 15 May 2026.