RhumbLine Advisers
UPB

RhumbLine Advisers’s Upstream Bio Inc UPB Stock Holding History

RhumbLine Advisers’s Portfolio UPB Stock Details UPB Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$371K Sell
41,203
-320
-0.8% -$5.76K ﹤0.01% 2793
2025
Q4 		$1.13M Sell
41,523
-7,883
-16% -$196K ﹤0.01% 2164
2025
Q3 		$929K Buy
49,406
+1,340
+3% +$20.8K ﹤0.01% 2291
2025
Q2 		$528K Buy
48,066
+34,739
+261% +$321K ﹤0.01% 2655
2025
Q1 		$81.6K Sell
13,327
-3,394
-20% -$32.4K ﹤0.01% 3454
2024
Q4 		$275K Buy
+16,721
New +$373K ﹤0.01% 3041

Other funds holding UPB

Fidelity Investments
Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return
O
OrbiMed New York $5.05B AUM 125.28% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
DC
Decheng Capital Menlo Park, California $661M AUM 299.97% 1-Year Est. Return
ES
Enavate Sciences Menlo Park, California $352M AUM 220.14% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
YIH
Y-Intercept (HK) Hong Kong $5.05B AUM 17.89% 1-Year Est. Return
Federated Hermes
Federated Hermes Pittsburgh, Pennsylvania $61.5B AUM 30.7% 1-Year Est. Return
Geode Capital Management
Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return
Millennium Management
Millennium Management New York $240B AUM 35.51% 1-Year Est. Return

RhumbLine Advisers's UPB Position: Q1 2026 in Review

RhumbLine Advisers reduced its Upstream Bio Inc (UPB) stake by 0.77% in Q1 2026, selling an estimated $5.76K and leaving 41,203 shares worth $371K. The position accounts for ﹤0.01% of the portfolio, ranked #2793.

RhumbLine Advisers first reported a position in UPB in Q4 2024 and has held it in 6 quarters since. The position peaked at $1.13M in Q4 2025. 140 funds tracked by Wall St. Rank hold UPB as of Q1 2026.

  • RhumbLine Advisers held 41,203 shares of Upstream Bio Inc worth $371K as of Q1 2026.
  • RhumbLine Advisers sold 320 Upstream Bio Inc shares in Q1 2026, an estimated $5.76K.
  • Upstream Bio Inc made up ﹤0.01% of RhumbLine Advisers's portfolio in Q1 2026, its #2793 holding.
  • RhumbLine Advisers first reported a position in Upstream Bio Inc in Q4 2024 and has held it in 6 quarters since.
  • RhumbLine Advisers's Upstream Bio Inc position peaked at $1.13M in Q4 2025.
  • 140 funds tracked by Wall St. Rank held Upstream Bio Inc as of Q1 2026.

Based on RhumbLine Advisers's 13F filing for Q1 2026, filed 12 May 2026.