RhumbLine Advisers
UPB

RhumbLine Advisers’s Upstream Bio Inc UPB Stock Holding History

RhumbLine Advisers’s Portfolio UPB Stock Details UPB Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$293K Buy
42,384
+1,181
+3% +$9.9K ﹤0.01% 3081
2026
Q1 		$371K Sell
41,203
-320
-0.8% -$5.76K ﹤0.01% 2793
2025
Q4 		$1.13M Sell
41,523
-7,883
-16% -$196K ﹤0.01% 2164
2025
Q3 		$929K Buy
49,406
+1,340
+3% +$20.8K ﹤0.01% 2291
2025
Q2 		$528K Buy
48,066
+34,739
+261% +$321K ﹤0.01% 2655
2025
Q1 		$81.6K Sell
13,327
-3,394
-20% -$32.4K ﹤0.01% 3454
2024
Q4 		$275K Buy
+16,721
New +$373K ﹤0.01% 3041

Other funds holding UPB

Fidelity Investments
Fidelity Investments Boston, Massachusetts $2.3T AUM 54.33% 1-Year Est. Return
O
OrbiMed New York $5.4B AUM 163.13% 1-Year Est. Return
Norges Bank
Norges Bank Oslo, Norway $1T AUM
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
DC
Decheng Capital Menlo Park, California $732M AUM 275.56% 1-Year Est. Return
ES
Enavate Sciences Menlo Park, California $345M AUM 134.64% 1-Year Est. Return
Vanguard Capital Management
Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM
Millennium Management
Millennium Management New York $276B AUM 44.8% 1-Year Est. Return
D.E. Shaw & Co
D.E. Shaw & Co New York $210B AUM 57.28% 1-Year Est. Return
JP Morgan Chase
JP Morgan Chase New York $1.81T AUM 41.13% 1-Year Est. Return

RhumbLine Advisers's UPB Position: Q2 2026 in Review

RhumbLine Advisers increased its Upstream Bio Inc (UPB) stake by 2.9% in Q2 2026, buying an estimated $9.9K and bringing the position to 42,384 shares worth $293K. The position accounts for ﹤0.01% of the portfolio, ranked #3081.

RhumbLine Advisers first reported a position in UPB in Q4 2024 and has held it in 7 quarters since. The position peaked at $1.13M in Q4 2025. 148 funds tracked by Wall St. Rank hold UPB as of Q2 2026.

  • RhumbLine Advisers held 42,384 shares of Upstream Bio Inc worth $293K as of Q2 2026.
  • RhumbLine Advisers bought 1,181 Upstream Bio Inc shares in Q2 2026, an estimated $9.9K.
  • Upstream Bio Inc made up ﹤0.01% of RhumbLine Advisers's portfolio in Q2 2026, its #3081 holding.
  • RhumbLine Advisers first reported a position in Upstream Bio Inc in Q4 2024 and has held it in 7 quarters since.
  • RhumbLine Advisers's Upstream Bio Inc position peaked at $1.13M in Q4 2025.
  • 148 funds tracked by Wall St. Rank held Upstream Bio Inc as of Q2 2026.

Based on RhumbLine Advisers's 13F filing for Q2 2026, filed 12 Aug 2026.