Bank of New York Mellon
UPB

Bank of New York Mellon’s Upstream Bio Inc UPB Stock Holding History

Bank of New York Mellon’s Portfolio UPB Stock Details UPB Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$593K Buy
85,747
+4,364
+5% +$36.6K ﹤0.01% 3662
2026
Q1 		$732K Sell
81,383
-3,470
-4% -$62.4K ﹤0.01% 3407
2025
Q4 		$2.3M Sell
84,853
-6,668
-7% -$166K ﹤0.01% 2754
2025
Q3 		$1.72M Buy
91,521
+11,755
+15% +$183K ﹤0.01% 2892
2025
Q2 		$876K Buy
79,766
+42,854
+116% +$396K ﹤0.01% 3205
2025
Q1 		$226K Sell
36,912
-1
-0% -$10 ﹤0.01% 3835
2024
Q4 		$607K Buy
+36,913
New +$824K ﹤0.01% 3420

Other funds holding UPB

BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
SAM
SEB Asset Management Stockholm $26.6B AUM
State Street
State Street Boston, Massachusetts $3.37T AUM 44.26% 1-Year Est. Return
YIH
Y-Intercept (HK) Hong Kong $5.05B AUM 17.89% 1-Year Est. Return
Walleye Capital
Walleye Capital New York $28B AUM 44.22% 1-Year Est. Return
Dimensional Fund Advisors
Dimensional Fund Advisors Austin, Texas $552B AUM 44.19% 1-Year Est. Return
Deutsche Bank
Deutsche Bank Frankfurt Am Main Ge, Germany $344B AUM 42.99% 1-Year Est. Return
N
Nuveen Charlotte, North Carolina $419B AUM 43.02% 1-Year Est. Return
GCP
GSA Capital Partners London, United Kingdom $1.59B AUM 39.81% 1-Year Est. Return
SAM
Simplify Asset Management Las Vegas, Nevada $7.19B AUM 6.88% 1-Year Est. Return

Bank of New York Mellon's UPB Position: Q2 2026 in Review

Bank of New York Mellon increased its Upstream Bio Inc (UPB) stake by 5.4% in Q2 2026, buying an estimated $36.6K and bringing the position to 85,747 shares worth $593K. The position accounts for ﹤0.01% of the portfolio, ranked #3662.

Bank of New York Mellon first reported a position in UPB in Q4 2024 and has held it in 7 quarters since. The position peaked at $2.3M in Q4 2025. 50 funds tracked by Wall St. Rank hold UPB as of Q2 2026.

  • Bank of New York Mellon held 85,747 shares of Upstream Bio Inc worth $593K as of Q2 2026.
  • Bank of New York Mellon bought 4,364 Upstream Bio Inc shares in Q2 2026, an estimated $36.6K.
  • Upstream Bio Inc made up ﹤0.01% of Bank of New York Mellon's portfolio in Q2 2026, its #3662 holding.
  • Bank of New York Mellon first reported a position in Upstream Bio Inc in Q4 2024 and has held it in 7 quarters since.
  • Bank of New York Mellon's Upstream Bio Inc position peaked at $2.3M in Q4 2025.
  • 50 funds tracked by Wall St. Rank held Upstream Bio Inc as of Q2 2026.

Based on Bank of New York Mellon's 13F filing for Q2 2026, filed 6 Aug 2026.