Nuveen
UPB

Nuveen’s Upstream Bio Inc UPB Stock Holding History

Nuveen’s Portfolio UPB Stock Details UPB Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$587K Buy
84,770
+9,234
+12% +$77.4K ﹤0.01% 3197
2026
Q1 		$680K Sell
75,536
-3,032
-4% -$54.5K ﹤0.01% 2733
2025
Q4 		$2.13M Buy
78,568
+8,686
+12% +$216K ﹤0.01% 2266
2025
Q3 		$1.31M Sell
69,882
-4,054
-5% -$63K ﹤0.01% 2492
2025
Q2 		$812K Buy
73,936
+51,350
+227% +$474K ﹤0.01% 2694
2025
Q1 		$138K Hold
22,586
– – ﹤0.01% 3181
2024
Q4 		$371K Buy
+22,586
New +$504K ﹤0.01% 3081

Other funds holding UPB

Fidelity Investments
Fidelity Investments Boston, Massachusetts $2.3T AUM 54.33% 1-Year Est. Return
O
OrbiMed New York $5.4B AUM 163.13% 1-Year Est. Return
Norges Bank
Norges Bank Oslo, Norway $1T AUM
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
DC
Decheng Capital Menlo Park, California $732M AUM 275.56% 1-Year Est. Return
ES
Enavate Sciences Menlo Park, California $345M AUM 134.64% 1-Year Est. Return
Vanguard Capital Management
Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM
Millennium Management
Millennium Management New York $276B AUM 44.8% 1-Year Est. Return
D.E. Shaw & Co
D.E. Shaw & Co New York $210B AUM 57.28% 1-Year Est. Return
JP Morgan Chase
JP Morgan Chase New York $1.81T AUM 41.13% 1-Year Est. Return

Nuveen's UPB Position: Q2 2026 in Review

Nuveen increased its Upstream Bio Inc (UPB) stake by 12% in Q2 2026, buying an estimated $77.4K and bringing the position to 84,770 shares worth $587K. The position accounts for ﹤0.01% of the portfolio, ranked #3197.

Nuveen first reported a position in UPB in Q4 2024 and has held it in 7 quarters since. The position peaked at $2.13M in Q4 2025. 148 funds tracked by Wall St. Rank hold UPB as of Q2 2026.

  • Nuveen held 84,770 shares of Upstream Bio Inc worth $587K as of Q2 2026.
  • Nuveen bought 9,234 Upstream Bio Inc shares in Q2 2026, an estimated $77.4K.
  • Upstream Bio Inc made up ﹤0.01% of Nuveen's portfolio in Q2 2026, its #3197 holding.
  • Nuveen first reported a position in Upstream Bio Inc in Q4 2024 and has held it in 7 quarters since.
  • Nuveen's Upstream Bio Inc position peaked at $2.13M in Q4 2025.
  • 148 funds tracked by Wall St. Rank held Upstream Bio Inc as of Q2 2026.

Based on Nuveen's 13F filing for Q2 2026, filed 11 Aug 2026.