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UPB

Nuveen’s Upstream Bio Inc UPB Stock Holding History

Nuveen’s Portfolio UPB Stock Details UPB Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$680K Sell
75,536
-3,032
-4% -$54.5K ﹤0.01% 2733
2025
Q4 		$2.13M Buy
78,568
+8,686
+12% +$216K ﹤0.01% 2266
2025
Q3 		$1.31M Sell
69,882
-4,054
-5% -$63K ﹤0.01% 2492
2025
Q2 		$812K Buy
73,936
+51,350
+227% +$474K ﹤0.01% 2694
2025
Q1 		$138K Hold
22,586
– – ﹤0.01% 3181
2024
Q4 		$371K Buy
+22,586
New +$504K ﹤0.01% 3081

Other funds holding UPB

Fidelity Investments
Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return
O
OrbiMed New York $5.05B AUM 125.28% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
DC
Decheng Capital Menlo Park, California $661M AUM 299.97% 1-Year Est. Return
ES
Enavate Sciences Menlo Park, California $352M AUM 220.14% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
YIH
Y-Intercept (HK) Hong Kong $5.05B AUM 17.89% 1-Year Est. Return
Federated Hermes
Federated Hermes Pittsburgh, Pennsylvania $61.5B AUM 30.7% 1-Year Est. Return
Geode Capital Management
Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return
Millennium Management
Millennium Management New York $240B AUM 35.51% 1-Year Est. Return

Nuveen's UPB Position: Q1 2026 in Review

Nuveen reduced its Upstream Bio Inc (UPB) stake by 3.9% in Q1 2026, selling an estimated $54.5K and leaving 75,536 shares worth $680K. The position accounts for ﹤0.01% of the portfolio, ranked #2733.

Nuveen first reported a position in UPB in Q4 2024 and has held it in 6 quarters since. The position peaked at $2.13M in Q4 2025. 140 funds tracked by Wall St. Rank hold UPB as of Q1 2026.

  • Nuveen held 75,536 shares of Upstream Bio Inc worth $680K as of Q1 2026.
  • Nuveen sold 3,032 Upstream Bio Inc shares in Q1 2026, an estimated $54.5K.
  • Upstream Bio Inc made up ﹤0.01% of Nuveen's portfolio in Q1 2026, its #2733 holding.
  • Nuveen first reported a position in Upstream Bio Inc in Q4 2024 and has held it in 6 quarters since.
  • Nuveen's Upstream Bio Inc position peaked at $2.13M in Q4 2025.
  • 140 funds tracked by Wall St. Rank held Upstream Bio Inc as of Q1 2026.

Based on Nuveen's 13F filing for Q1 2026, filed 30 Apr 2026.