State Street
UPB

State Street’s Upstream Bio Inc UPB Stock Holding History

State Street’s Portfolio UPB Stock Details UPB Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$6.35M Sell
705,350
-613,876
-47% -$11M ﹤0.01% 2837
2025
Q4 		$35.8M Buy
1,319,226
+204,645
+18% +$5.09M ﹤0.01% 1931
2025
Q3 		$21M Buy
1,114,581
+633,206
+132% +$9.84M ﹤0.01% 2215
2025
Q2 		$5.29M Buy
481,375
+185,788
+63% +$1.72M ﹤0.01% 2919
2025
Q1 		$1.81M Buy
295,587
+48,400
+20% +$462K ﹤0.01% 3283
2024
Q4 		$4.06M Buy
+247,187
New +$5.52M ﹤0.01% 3048

Other funds holding UPB

Fidelity Investments
Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return
O
OrbiMed New York $5.05B AUM 125.28% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
DC
Decheng Capital Menlo Park, California $661M AUM 299.97% 1-Year Est. Return
ES
Enavate Sciences Menlo Park, California $352M AUM 220.14% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
YIH
Y-Intercept (HK) Hong Kong $5.05B AUM 17.89% 1-Year Est. Return
Federated Hermes
Federated Hermes Pittsburgh, Pennsylvania $61.5B AUM 30.7% 1-Year Est. Return
Geode Capital Management
Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return
Millennium Management
Millennium Management New York $240B AUM 35.51% 1-Year Est. Return

State Street's UPB Position: Q1 2026 in Review

State Street reduced its Upstream Bio Inc (UPB) stake by 47% in Q1 2026, selling an estimated $11M and leaving 705,350 shares worth $6.35M. The position accounts for ﹤0.01% of the portfolio, ranked #2837.

State Street first reported a position in UPB in Q4 2024 and has held it in 6 quarters since. The position peaked at $35.8M in Q4 2025. 140 funds tracked by Wall St. Rank hold UPB as of Q1 2026.

  • State Street held 705,350 shares of Upstream Bio Inc worth $6.35M as of Q1 2026.
  • State Street sold 613,876 Upstream Bio Inc shares in Q1 2026, an estimated $11M.
  • Upstream Bio Inc made up ﹤0.01% of State Street's portfolio in Q1 2026, its #2837 holding.
  • State Street first reported a position in Upstream Bio Inc in Q4 2024 and has held it in 6 quarters since.
  • State Street's Upstream Bio Inc position peaked at $35.8M in Q4 2025.
  • 140 funds tracked by Wall St. Rank held Upstream Bio Inc as of Q1 2026.

Based on State Street's 13F filing for Q1 2026, filed 15 May 2026.