State Street’s Upstream Bio, Inc. Common Stock UPB Stock Holding History

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Shares Change %	Capital Flow	Portfolio Weight	Portfolio Position
2025 Q2	$5.29M	Buy	481,375 +185,788	+63%	+$2.04M	﹤0.01%	2919
2025 Q1	$1.81M	Buy	295,587 +48,400	+20%	+$296K	﹤0.01%	3283
2024 Q4	$4.06M	Buy	+247,187	New	+$4.06M	﹤0.01%	3048