State Street
UPB

State Street’s Upstream Bio Inc UPB Stock Holding History

State Street’s Portfolio UPB Stock Details UPB Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$5.3M Buy
766,323
+60,973
+9% +$511K ﹤0.01% 2984
2026
Q1 		$6.35M Sell
705,350
-613,876
-47% -$11M ﹤0.01% 2837
2025
Q4 		$35.8M Buy
1,319,226
+204,645
+18% +$5.09M ﹤0.01% 1931
2025
Q3 		$21M Buy
1,114,581
+633,206
+132% +$9.84M ﹤0.01% 2215
2025
Q2 		$5.29M Buy
481,375
+185,788
+63% +$1.72M ﹤0.01% 2919
2025
Q1 		$1.81M Buy
295,587
+48,400
+20% +$462K ﹤0.01% 3283
2024
Q4 		$4.06M Buy
+247,187
New +$5.52M ﹤0.01% 3048

Other funds holding UPB

Fidelity Investments
Fidelity Investments Boston, Massachusetts $2.3T AUM 54.33% 1-Year Est. Return
O
OrbiMed New York $5.4B AUM 163.13% 1-Year Est. Return
Norges Bank
Norges Bank Oslo, Norway $1T AUM
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
DC
Decheng Capital Menlo Park, California $732M AUM 275.56% 1-Year Est. Return
ES
Enavate Sciences Menlo Park, California $345M AUM 134.64% 1-Year Est. Return
Vanguard Capital Management
Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM
Millennium Management
Millennium Management New York $276B AUM 44.8% 1-Year Est. Return
D.E. Shaw & Co
D.E. Shaw & Co New York $210B AUM 57.28% 1-Year Est. Return
JP Morgan Chase
JP Morgan Chase New York $1.81T AUM 41.13% 1-Year Est. Return

State Street's UPB Position: Q2 2026 in Review

State Street increased its Upstream Bio Inc (UPB) stake by 8.6% in Q2 2026, buying an estimated $511K and bringing the position to 766,323 shares worth $5.3M. The position accounts for ﹤0.01% of the portfolio, ranked #2984.

State Street first reported a position in UPB in Q4 2024 and has held it in 7 quarters since. The position peaked at $35.8M in Q4 2025. 149 funds tracked by Wall St. Rank hold UPB as of Q2 2026.

  • State Street held 766,323 shares of Upstream Bio Inc worth $5.3M as of Q2 2026.
  • State Street bought 60,973 Upstream Bio Inc shares in Q2 2026, an estimated $511K.
  • Upstream Bio Inc made up ﹤0.01% of State Street's portfolio in Q2 2026, its #2984 holding.
  • State Street first reported a position in Upstream Bio Inc in Q4 2024 and has held it in 7 quarters since.
  • State Street's Upstream Bio Inc position peaked at $35.8M in Q4 2025.
  • 149 funds tracked by Wall St. Rank held Upstream Bio Inc as of Q2 2026.

Based on State Street's 13F filing for Q2 2026, filed 7 Aug 2026.