Barclays
UPB

Barclays’s Upstream Bio Inc UPB Stock Holding History

Barclays’s Portfolio UPB Stock Details UPB Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$202K Buy
29,208
+4,488
+18% +$37.6K ﹤0.01% 3690
2026
Q1 		$222K Sell
24,720
-499,779
-95% -$8.99M ﹤0.01% 3630
2025
Q4 		$14.2M Buy
524,499
+439,184
+515% +$10.9M ﹤0.01% 1443
2025
Q3 		$1.6M Sell
85,315
-11,675
-12% -$181K ﹤0.01% 3034
2025
Q2 		$1.06M Buy
96,990
+71,997
+288% +$665K ﹤0.01% 3300
2025
Q1 		$153K Sell
24,993
-2,024
-7% -$19.3K ﹤0.01% 4193
2024
Q4 		$444K Buy
+27,017
New +$603K ﹤0.01% 3894

Other funds holding UPB

Fidelity Investments
Fidelity Investments Boston, Massachusetts $2.3T AUM 54.33% 1-Year Est. Return
O
OrbiMed New York $5.4B AUM 163.13% 1-Year Est. Return
Norges Bank
Norges Bank Oslo, Norway $1T AUM
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
DC
Decheng Capital Menlo Park, California $732M AUM 275.56% 1-Year Est. Return
ES
Enavate Sciences Menlo Park, California $345M AUM 134.64% 1-Year Est. Return
Vanguard Capital Management
Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM
Millennium Management
Millennium Management New York $276B AUM 44.8% 1-Year Est. Return
D.E. Shaw & Co
D.E. Shaw & Co New York $210B AUM 57.28% 1-Year Est. Return
JP Morgan Chase
JP Morgan Chase New York $1.81T AUM 41.13% 1-Year Est. Return

Barclays's UPB Position: Q2 2026 in Review

Barclays increased its Upstream Bio Inc (UPB) stake by 18% in Q2 2026, buying an estimated $37.6K and bringing the position to 29,208 shares worth $202K. The position accounts for ﹤0.01% of the portfolio, ranked #3690.

Barclays first reported a position in UPB in Q4 2024 and has held it in 7 quarters since. The position peaked at $14.2M in Q4 2025. 148 funds tracked by Wall St. Rank hold UPB as of Q2 2026.

  • Barclays held 29,208 shares of Upstream Bio Inc worth $202K as of Q2 2026.
  • Barclays bought 4,488 Upstream Bio Inc shares in Q2 2026, an estimated $37.6K.
  • Upstream Bio Inc made up ﹤0.01% of Barclays's portfolio in Q2 2026, its #3690 holding.
  • Barclays first reported a position in Upstream Bio Inc in Q4 2024 and has held it in 7 quarters since.
  • Barclays's Upstream Bio Inc position peaked at $14.2M in Q4 2025.
  • 148 funds tracked by Wall St. Rank held Upstream Bio Inc as of Q2 2026.

Based on Barclays's 13F filing for Q2 2026, filed 14 Aug 2026.