Barclays
UPB

Barclays’s Upstream Bio Inc UPB Stock Holding History

Barclays’s Portfolio UPB Stock Details UPB Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$222K Sell
24,720
-499,779
-95% -$8.99M ﹤0.01% 3630
2025
Q4 		$14.2M Buy
524,499
+439,184
+515% +$10.9M ﹤0.01% 1443
2025
Q3 		$1.6M Sell
85,315
-11,675
-12% -$181K ﹤0.01% 3034
2025
Q2 		$1.06M Buy
96,990
+71,997
+288% +$665K ﹤0.01% 3300
2025
Q1 		$153K Sell
24,993
-2,024
-7% -$19.3K ﹤0.01% 4193
2024
Q4 		$444K Buy
+27,017
New +$603K ﹤0.01% 3894

Other funds holding UPB

Fidelity Investments
Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return
O
OrbiMed New York $5.05B AUM 125.28% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
DC
Decheng Capital Menlo Park, California $661M AUM 299.97% 1-Year Est. Return
ES
Enavate Sciences Menlo Park, California $352M AUM 220.14% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
YIH
Y-Intercept (HK) Hong Kong $5.05B AUM 17.89% 1-Year Est. Return
Federated Hermes
Federated Hermes Pittsburgh, Pennsylvania $61.5B AUM 30.7% 1-Year Est. Return
Geode Capital Management
Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return
Millennium Management
Millennium Management New York $240B AUM 35.51% 1-Year Est. Return

Barclays's UPB Position: Q1 2026 in Review

Barclays reduced its Upstream Bio Inc (UPB) stake by 95% in Q1 2026, selling an estimated $8.99M and leaving 24,720 shares worth $222K. The position accounts for ﹤0.01% of the portfolio, ranked #3630.

Barclays first reported a position in UPB in Q4 2024 and has held it in 6 quarters since. The position peaked at $14.2M in Q4 2025. 140 funds tracked by Wall St. Rank hold UPB as of Q1 2026.

  • Barclays held 24,720 shares of Upstream Bio Inc worth $222K as of Q1 2026.
  • Barclays sold 499,779 Upstream Bio Inc shares in Q1 2026, an estimated $8.99M.
  • Upstream Bio Inc made up ﹤0.01% of Barclays's portfolio in Q1 2026, its #3630 holding.
  • Barclays first reported a position in Upstream Bio Inc in Q4 2024 and has held it in 6 quarters since.
  • Barclays's Upstream Bio Inc position peaked at $14.2M in Q4 2025.
  • 140 funds tracked by Wall St. Rank held Upstream Bio Inc as of Q1 2026.

Based on Barclays's 13F filing for Q1 2026, filed 15 May 2026.