Northern Trust
UPB

Northern Trust’s Upstream Bio Inc UPB Stock Holding History

Northern Trust’s Portfolio UPB Stock Details UPB Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$2.06M Buy
297,346
+36,354
+14% +$305K ﹤0.01% 3124
2026
Q1 		$2.35M Buy
260,992
+24,193
+10% +$435K ﹤0.01% 2885
2025
Q4 		$6.43M Sell
236,799
-17,920
-7% -$446K ﹤0.01% 2329
2025
Q3 		$4.79M Buy
254,719
+25,416
+11% +$395K ﹤0.01% 2530
2025
Q2 		$2.52M Buy
229,303
+91,532
+66% +$845K ﹤0.01% 2854
2025
Q1 		$843K Sell
137,771
-5,950
-4% -$56.8K ﹤0.01% 3352
2024
Q4 		$2.36M Buy
+143,721
New +$3.21M ﹤0.01% 2929

Other funds holding UPB

Fidelity Investments
Fidelity Investments Boston, Massachusetts $2.3T AUM 54.33% 1-Year Est. Return
O
OrbiMed New York $5.4B AUM 163.13% 1-Year Est. Return
Norges Bank
Norges Bank Oslo, Norway $1T AUM
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
DC
Decheng Capital Menlo Park, California $732M AUM 275.56% 1-Year Est. Return
ES
Enavate Sciences Menlo Park, California $345M AUM 134.64% 1-Year Est. Return
Vanguard Capital Management
Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM
Millennium Management
Millennium Management New York $276B AUM 44.8% 1-Year Est. Return
D.E. Shaw & Co
D.E. Shaw & Co New York $210B AUM 57.28% 1-Year Est. Return
JP Morgan Chase
JP Morgan Chase New York $1.81T AUM 41.13% 1-Year Est. Return

Northern Trust's UPB Position: Q2 2026 in Review

Northern Trust increased its Upstream Bio Inc (UPB) stake by 14% in Q2 2026, buying an estimated $305K and bringing the position to 297,346 shares worth $2.06M. The position accounts for ﹤0.01% of the portfolio, ranked #3124.

Northern Trust first reported a position in UPB in Q4 2024 and has held it in 7 quarters since. The position peaked at $6.43M in Q4 2025. 148 funds tracked by Wall St. Rank hold UPB as of Q2 2026.

  • Northern Trust held 297,346 shares of Upstream Bio Inc worth $2.06M as of Q2 2026.
  • Northern Trust bought 36,354 Upstream Bio Inc shares in Q2 2026, an estimated $305K.
  • Upstream Bio Inc made up ﹤0.01% of Northern Trust's portfolio in Q2 2026, its #3124 holding.
  • Northern Trust first reported a position in Upstream Bio Inc in Q4 2024 and has held it in 7 quarters since.
  • Northern Trust's Upstream Bio Inc position peaked at $6.43M in Q4 2025.
  • 148 funds tracked by Wall St. Rank held Upstream Bio Inc as of Q2 2026.

Based on Northern Trust's 13F filing for Q2 2026, filed 13 Aug 2026.