Northern Trust
UPB

Northern Trust’s Upstream Bio Inc UPB Stock Holding History

Northern Trust’s Portfolio UPB Stock Details UPB Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$2.35M Buy
260,992
+24,193
+10% +$435K ﹤0.01% 2885
2025
Q4 		$6.43M Sell
236,799
-17,920
-7% -$446K ﹤0.01% 2329
2025
Q3 		$4.79M Buy
254,719
+25,416
+11% +$395K ﹤0.01% 2530
2025
Q2 		$2.52M Buy
229,303
+91,532
+66% +$845K ﹤0.01% 2854
2025
Q1 		$843K Sell
137,771
-5,950
-4% -$56.8K ﹤0.01% 3352
2024
Q4 		$2.36M Buy
+143,721
New +$3.21M ﹤0.01% 2929

Other funds holding UPB

Fidelity Investments
Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return
O
OrbiMed New York $5.05B AUM 125.28% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
DC
Decheng Capital Menlo Park, California $661M AUM 299.97% 1-Year Est. Return
ES
Enavate Sciences Menlo Park, California $352M AUM 220.14% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
YIH
Y-Intercept (HK) Hong Kong $5.05B AUM 17.89% 1-Year Est. Return
Federated Hermes
Federated Hermes Pittsburgh, Pennsylvania $61.5B AUM 30.7% 1-Year Est. Return
Geode Capital Management
Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return
Millennium Management
Millennium Management New York $240B AUM 35.51% 1-Year Est. Return

Northern Trust's UPB Position: Q1 2026 in Review

Northern Trust increased its Upstream Bio Inc (UPB) stake by 10% in Q1 2026, buying an estimated $435K and bringing the position to 260,992 shares worth $2.35M. The position accounts for ﹤0.01% of the portfolio, ranked #2885.

Northern Trust first reported a position in UPB in Q4 2024 and has held it in 6 quarters since. The position peaked at $6.43M in Q4 2025. 140 funds tracked by Wall St. Rank hold UPB as of Q1 2026.

  • Northern Trust held 260,992 shares of Upstream Bio Inc worth $2.35M as of Q1 2026.
  • Northern Trust bought 24,193 Upstream Bio Inc shares in Q1 2026, an estimated $435K.
  • Upstream Bio Inc made up ﹤0.01% of Northern Trust's portfolio in Q1 2026, its #2885 holding.
  • Northern Trust first reported a position in Upstream Bio Inc in Q4 2024 and has held it in 6 quarters since.
  • Northern Trust's Upstream Bio Inc position peaked at $6.43M in Q4 2025.
  • 140 funds tracked by Wall St. Rank held Upstream Bio Inc as of Q1 2026.

Based on Northern Trust's 13F filing for Q1 2026, filed 14 May 2026.