Susquehanna International Group
UPB

Susquehanna International Group’s Upstream Bio Inc UPB Stock Holding History

Susquehanna International Group’s Portfolio UPB Stock Details UPB Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$144K Sell
15,961
-39,880
-71% -$717K ﹤0.01% 12058
2025
Q4 		$1.52M Buy
+55,841
New +$1.39M ﹤0.01% 6218
2025
Q3 		– Sell
-42,263
Closed -$464K – 14233
2025
Q2 		$464K Buy
42,263
+20,999
+99% +$194K ﹤0.01% 9344
2025
Q1 		$130K Buy
+21,264
New +$203K ﹤0.01% 11337

Other funds holding UPB

Fidelity Investments
Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return
O
OrbiMed New York $5.05B AUM 125.28% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
DC
Decheng Capital Menlo Park, California $661M AUM 299.97% 1-Year Est. Return
ES
Enavate Sciences Menlo Park, California $352M AUM 220.14% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
YIH
Y-Intercept (HK) Hong Kong $5.05B AUM 17.89% 1-Year Est. Return
Federated Hermes
Federated Hermes Pittsburgh, Pennsylvania $61.5B AUM 30.7% 1-Year Est. Return
Geode Capital Management
Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return
Millennium Management
Millennium Management New York $240B AUM 35.51% 1-Year Est. Return

Susquehanna International Group's UPB Position: Q1 2026 in Review

Susquehanna International Group reduced its Upstream Bio Inc (UPB) stake by 71% in Q1 2026, selling an estimated $717K and leaving 15,961 shares worth $144K. The position accounts for ﹤0.01% of the portfolio, ranked #12058.

Susquehanna International Group first reported a position in UPB in Q1 2025 and has held it in 4 quarters since. The position peaked at $1.52M in Q4 2025. 140 funds tracked by Wall St. Rank hold UPB as of Q1 2026.

  • Susquehanna International Group held 15,961 shares of Upstream Bio Inc worth $144K as of Q1 2026.
  • Susquehanna International Group sold 39,880 Upstream Bio Inc shares in Q1 2026, an estimated $717K.
  • Upstream Bio Inc made up ﹤0.01% of Susquehanna International Group's portfolio in Q1 2026, its #12058 holding.
  • Susquehanna International Group first reported a position in Upstream Bio Inc in Q1 2025 and has held it in 4 quarters since.
  • Susquehanna International Group's Upstream Bio Inc position peaked at $1.52M in Q4 2025.
  • 140 funds tracked by Wall St. Rank held Upstream Bio Inc as of Q1 2026.

Based on Susquehanna International Group's 13F filing for Q1 2026, filed 15 May 2026.