Balyasny Asset Management
UPB

Balyasny Asset Management’s Upstream Bio Inc UPB Stock Holding History

Balyasny Asset Management’s Portfolio UPB Stock Details UPB Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2025
Q4 		– Sell
-73,131
Closed -$1.38M – 3652
2025
Q3 		$1.38M Buy
+73,131
New +$1.14M ﹤0.01% 1987
2025
Q1 		– Sell
-301,152
Closed -$4.95M – 3387
2024
Q4 		$4.95M Buy
+301,152
New +$6.72M 0.01% 1289

Other funds holding UPB

Fidelity Investments
Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return
O
OrbiMed New York $5.05B AUM 125.28% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
DC
Decheng Capital Menlo Park, California $661M AUM 299.97% 1-Year Est. Return
Norges Bank
Norges Bank Oslo, Norway $935B AUM
ES
Enavate Sciences Menlo Park, California $352M AUM 220.14% 1-Year Est. Return
Vanguard Group
Vanguard Group Malvern, Pennsylvania $6.9T AUM 27.45% 1-Year Est. Return
UBS Group
UBS Group Zurich, Switzerland $666B AUM 30.12% 1-Year Est. Return
Janus Henderson Group
Janus Henderson Group London, United Kingdom $209B AUM 37.72% 1-Year Est. Return
AS
Altshuler Shaham Tel Aviv, Israel $5.54B AUM 44.68% 1-Year Est. Return

Balyasny Asset Management's UPB Position: Q4 2025 in Review

Balyasny Asset Management sold out of Upstream Bio Inc (UPB) in Q4 2025, closing a stake of 73,131 shares — an estimated $1.38M sold.

Balyasny Asset Management first reported a position in UPB in Q4 2024 and held it in 2 quarters. The position peaked at $4.95M in Q4 2024. 133 funds tracked by Wall St. Rank hold UPB as of Q4 2025.

  • Balyasny Asset Management reported no remaining Upstream Bio Inc position as of Q4 2025 after selling out during the quarter.
  • Balyasny Asset Management sold 73,131 Upstream Bio Inc shares in Q4 2025, an estimated $1.38M.
  • Balyasny Asset Management first reported a position in Upstream Bio Inc in Q4 2024 and held it in 2 quarters.
  • Balyasny Asset Management's Upstream Bio Inc position peaked at $4.95M in Q4 2024.
  • 133 funds tracked by Wall St. Rank held Upstream Bio Inc as of Q4 2025.

Based on Balyasny Asset Management's 13F filing for Q4 2025, filed 17 Feb 2026.