Vanguard Group
UPB

Vanguard Group’s Upstream Bio Inc UPB Stock Holding History

Vanguard Group’s Portfolio UPB Stock Details UPB Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2025
Q4 		$64.8M Sell
2,388,439
-54,112
-2% -$1.35M ﹤0.01% 2033
2025
Q3 		$45.9M Buy
2,442,551
+271,718
+13% +$4.22M ﹤0.01% 2198
2025
Q2 		$23.8M Buy
2,170,833
+1,263,807
+139% +$11.7M ﹤0.01% 2477
2025
Q1 		$5.55M Sell
907,026
-7,995
-0.9% -$76.4K ﹤0.01% 3128
2024
Q4 		$15M Buy
+915,021
New +$20.4M ﹤0.01% 2738

Other funds holding UPB

Fidelity Investments
Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return
O
OrbiMed New York $5.05B AUM 125.28% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
DC
Decheng Capital Menlo Park, California $661M AUM 299.97% 1-Year Est. Return
Norges Bank
Norges Bank Oslo, Norway $935B AUM
ES
Enavate Sciences Menlo Park, California $352M AUM 220.14% 1-Year Est. Return
UBS Group
UBS Group Zurich, Switzerland $666B AUM 30.12% 1-Year Est. Return
Janus Henderson Group
Janus Henderson Group London, United Kingdom $209B AUM 37.72% 1-Year Est. Return
AS
Altshuler Shaham Tel Aviv, Israel $5.54B AUM 44.68% 1-Year Est. Return
BCLSI
Bain Capital Life Sciences Investors Boston, Massachusetts $1.11B AUM 171.34% 1-Year Est. Return

Vanguard Group's UPB Position: Q4 2025 in Review

Vanguard Group reduced its Upstream Bio Inc (UPB) stake by 2.2% in Q4 2025, selling an estimated $1.35M and leaving 2,388,439 shares worth $64.8M. The position accounts for ﹤0.01% of the portfolio, ranked #2033.

Vanguard Group first reported a position in UPB in Q4 2024 and has held it in 5 quarters since. 133 funds tracked by Wall St. Rank hold UPB as of Q4 2025.

  • Vanguard Group held 2,388,439 shares of Upstream Bio Inc worth $64.8M as of Q4 2025.
  • Vanguard Group sold 54,112 Upstream Bio Inc shares in Q4 2025, an estimated $1.35M.
  • Upstream Bio Inc made up ﹤0.01% of Vanguard Group's portfolio in Q4 2025, its #2033 holding.
  • Vanguard Group first reported a position in Upstream Bio Inc in Q4 2024 and has held it in 5 quarters since.
  • 133 funds tracked by Wall St. Rank held Upstream Bio Inc as of Q4 2025.

Based on Vanguard Group's 13F filing for Q4 2025, filed 29 Jan 2026.