UPB

Upstream Bio, Inc. Common Stock

82 hedge funds and large institutions have $531M invested in Upstream Bio, Inc. Common Stock in 2025 Q2 according to their latest regulatory filings, with 14 funds opening new positions, 41 increasing their positions, 13 reducing their positions, and 10 closing their positions.

Holders
82
Holders Change
+4
Holders Change %
+5.13%
% of All Funds
1.1%
Holding in Top 10
4
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
0.05%
New
14
Increased
41
Reduced
13
Closed
10
Calls
Puts
Net Calls
Net Calls Change
Name Market Value Shares Shares
Change
Shares
Change %
Northern Trust
26
Northern Trust
Illinois
$2.52M 229,303 +91,532 +66%
LCM
27
Lynx1 Capital Management
Puerto Rico
$2.41M 219,247
Charles Schwab
28
Charles Schwab
California
$1.96M 178,253 +46,080 +35%
VCIM
29
Velan Capital Investment Management
Georgia
$1.17M 107,000
Morgan Stanley
30
Morgan Stanley
New York
$1.09M 99,308 +47,917 +93%
Barclays
31
Barclays
United Kingdom
$1.07M 96,990 +71,997 +288%
Alyeska Investment Group
32
Alyeska Investment Group
Illinois
$933K 85,000
Bank of New York Mellon
33
Bank of New York Mellon
New York
$876K 79,766 +42,854 +116%
NL
34
Nuveen LLC
North Carolina
$812K 73,936 +51,350 +227%
RhumbLine Advisers
35
RhumbLine Advisers
Massachusetts
$528K 48,066 +34,739 +261%
Susquehanna International Group
36
Susquehanna International Group
Pennsylvania
$464K 42,263 +20,999 +99%
Verition Fund Management
37
Verition Fund Management
Connecticut
$368K 33,505 +33,505 New
AQR Capital Management
38
AQR Capital Management
Connecticut
$327K 29,752 +10,930 +58%
AA
39
ALPS Advisors
Colorado
$318K 28,976 -10,103 -26%
AllianceBernstein
40
AllianceBernstein
Tennessee
$270K 24,560 -1,066,626 -98%
Deutsche Bank
41
Deutsche Bank
Germany
$257K 23,403 +8,211 +54%
Wells Fargo
42
Wells Fargo
California
$246K 22,364 +13,114 +142%
American Century Companies
43
American Century Companies
Missouri
$246K 22,362 +22,362 New
MIM
44
MetLife Investment Management
New Jersey
$238K 21,691 +10,657 +97%
IIM
45
INTECH Investment Management
Florida
$234K 21,290 +6,005 +39%
Mirae Asset Global ETFs Holdings
46
Mirae Asset Global ETFs Holdings
Hong Kong
$210K 19,084 +8,788 +85%
Bank of America
47
Bank of America
North Carolina
$198K 18,031 +7,500 +71%
T. Rowe Price Associates
48
T. Rowe Price Associates
Maryland
$192K 17,448 +17,448 New
JPMorgan Chase & Co
49
JPMorgan Chase & Co
New York
$181K 16,469 +1,275 +8%
Invesco
50
Invesco
Georgia
$179K 16,300 +985 +6%