UPB
Upstream Bio Inc
92 hedge funds and large institutions have $836M invested in Upstream Bio Inc in 2025 Q3 according to their latest regulatory filings, with 22 funds opening new positions, 36 increasing their positions, 22 reducing their positions, and 10 closing their positions.
New
Increased
Maintained
Reduced
Closed
more call options, than puts
Call options by funds: $ | Put options by funds: $
more first-time investments, than exits
New positions opened: | Existing positions closed:
more repeat investments, than reductions
Existing positions increased: | Existing positions reduced:
more capital invested
Capital invested by funds: $ → $
25% more funds holding in top 10
Funds holding in top 10: 4 → 5 (+1)
12% more funds holding
Funds holding: 82 → 92 (+10)
7.41% less ownership
Funds ownership: 89.89% → 82.47% (-7.4%)
Holders
92
Holding in Top 10
5
Calls
$8.02M
Puts
$520K
Top Buyers
| 1 | +$11.9M | |
| 2 | +$10.9M | |
| 3 | +$10.8M | |
| 4 |
BlackRock
New York
|
+$9.54M |
| 5 |
Vanguard Group
Malvern,
Pennsylvania
|
+$5.11M |
Top Sellers
| 1 | -$37.2M | |
| 2 | -$21.2M | |
| 3 | -$15.8M | |
| 4 |
TCM
TCG Crossover Management
Palo Alto,
California
|
-$12.9M |
| 5 |
OFM
Omega Fund Management
Boston,
Massachusetts
|
-$12.8M |
