California State Teachers Retirement System (CalSTRS)
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California State Teachers Retirement System (CalSTRS)’s Upstream Bio Inc UPB Stock Holding History

California State Teachers Retirement System (CalSTRS)’s Portfolio UPB Stock Details UPB Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$267K Sell
38,634
-1,027
-3% -$8.61K ﹤0.01% 2206
2026
Q1 		$357K Buy
39,661
+25,009
+171% +$450K ﹤0.01% 2136
2025
Q4 		$398K Buy
14,652
+12,476
+573% +$311K ﹤0.01% 2167
2025
Q3 		$40.9K Buy
2,176
+2
+0.1% +$31 ﹤0.01% 2320
2025
Q2 		$23.9K Buy
2,174
+884
+69% +$8.16K ﹤0.01% 2453
2025
Q1 		$7.89K Hold
1,290
– – ﹤0.01% 2837
2024
Q4 		$21.2K Buy
+1,290
New +$28.8K ﹤0.01% 2585

Other funds holding UPB

Fidelity Investments
Fidelity Investments Boston, Massachusetts $2.3T AUM 54.33% 1-Year Est. Return
OrbiMed
OrbiMed New York $5.4B AUM 163.13% 1-Year Est. Return
Norges Bank
Norges Bank Oslo, Norway $1T AUM
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
DC
Decheng Capital Menlo Park, California $732M AUM 275.56% 1-Year Est. Return
ES
Enavate Sciences Menlo Park, California $345M AUM 134.64% 1-Year Est. Return
Vanguard Capital Management
Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM
Millennium Management
Millennium Management New York $276B AUM 44.8% 1-Year Est. Return
D.E. Shaw & Co
D.E. Shaw & Co New York $210B AUM 57.28% 1-Year Est. Return
JP Morgan Chase
JP Morgan Chase New York $1.81T AUM 41.13% 1-Year Est. Return

California State Teachers Retirement System (CalSTRS)'s UPB Position: Q2 2026 in Review

California State Teachers Retirement System (CalSTRS) reduced its Upstream Bio Inc (UPB) stake by 2.6% in Q2 2026, selling an estimated $8.61K and leaving 38,634 shares worth $267K. The position accounts for ﹤0.01% of the portfolio, ranked #2206.

California State Teachers Retirement System (CalSTRS) first reported a position in UPB in Q4 2024 and has held it in 7 quarters since. The position peaked at $398K in Q4 2025. 148 funds tracked by Wall St. Rank hold UPB as of Q2 2026.

  • California State Teachers Retirement System (CalSTRS) held 38,634 shares of Upstream Bio Inc worth $267K as of Q2 2026.
  • California State Teachers Retirement System (CalSTRS) sold 1,027 Upstream Bio Inc shares in Q2 2026, an estimated $8.61K.
  • Upstream Bio Inc made up ﹤0.01% of California State Teachers Retirement System (CalSTRS)'s portfolio in Q2 2026, its #2206 holding.
  • California State Teachers Retirement System (CalSTRS) first reported a position in Upstream Bio Inc in Q4 2024 and has held it in 7 quarters since.
  • California State Teachers Retirement System (CalSTRS)'s Upstream Bio Inc position peaked at $398K in Q4 2025.
  • 148 funds tracked by Wall St. Rank held Upstream Bio Inc as of Q2 2026.

Based on California State Teachers Retirement System (CalSTRS)'s 13F filing for Q2 2026, filed 24 Aug 2026.