Federated Hermes’s Upstream Bio Inc UPB Stock Holding History

Federated Hermes’s Portfolio UPB Stock Details UPB Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2026 Q1	$8.82M	Buy	979,758 +979,276	+203,169%	+$17.6M	0.01%	676
2025 Q4	$13.1K	Buy	+482	New	+$12K	﹤0.01%	1814

Other funds holding UPB

Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return

OrbiMed New York $5.05B AUM 125.28% 1-Year Est. Return

BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return

Decheng Capital Menlo Park, California $661M AUM 299.97% 1-Year Est. Return

Enavate Sciences Menlo Park, California $352M AUM 220.14% 1-Year Est. Return

VCM

Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM

YIH

Y-Intercept (HK) Hong Kong $5.05B AUM 17.89% 1-Year Est. Return

Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return

Millennium Management New York $240B AUM 35.51% 1-Year Est. Return

SAM

SEB Asset Management Stockholm $23.4B AUM

Federated Hermes's UPB Position: Q1 2026 in Review

Federated Hermes increased its Upstream Bio Inc (UPB) stake by 203,169% in Q1 2026, buying an estimated $17.6M and bringing the position to 979,758 shares worth $8.82M. The position accounts for 0.01% of the portfolio, ranked #676.

Federated Hermes first reported a position in UPB in Q4 2025 and has held it in 2 quarters since. 140 funds tracked by Wall St. Rank hold UPB as of Q1 2026.

Federated Hermes held 979,758 shares of Upstream Bio Inc worth $8.82M as of Q1 2026.
Federated Hermes bought 979,276 Upstream Bio Inc shares in Q1 2026, an estimated $17.6M.
Upstream Bio Inc made up 0.01% of Federated Hermes's portfolio in Q1 2026, its #676 holding.
Federated Hermes first reported a position in Upstream Bio Inc in Q4 2025 and has held it in 2 quarters since.
140 funds tracked by Wall St. Rank held Upstream Bio Inc as of Q1 2026.

Based on Federated Hermes's 13F filing for Q1 2026, filed 11 May 2026.