Renaissance Technologies
UPB

Renaissance Technologies’s Upstream Bio Inc UPB Stock Holding History

Renaissance Technologies’s Portfolio UPB Stock Details UPB Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$909K Buy
131,300
+69,200
+111% +$580K ﹤0.01% 2351
2026
Q1 		$559K Buy
62,100
+45,700
+279% +$822K ﹤0.01% 2558
2025
Q4 		$445K Buy
+16,400
New +$408K ﹤0.01% 2620

Other funds holding UPB

Fidelity Investments
Fidelity Investments Boston, Massachusetts $2.3T AUM 54.33% 1-Year Est. Return
O
OrbiMed New York $5.4B AUM 163.13% 1-Year Est. Return
Norges Bank
Norges Bank Oslo, Norway $1T AUM
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
DC
Decheng Capital Menlo Park, California $732M AUM 275.56% 1-Year Est. Return
ES
Enavate Sciences Menlo Park, California $345M AUM 134.64% 1-Year Est. Return
Vanguard Capital Management
Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM
Millennium Management
Millennium Management New York $276B AUM 44.8% 1-Year Est. Return
D.E. Shaw & Co
D.E. Shaw & Co New York $210B AUM 57.28% 1-Year Est. Return
JP Morgan Chase
JP Morgan Chase New York $1.81T AUM 41.13% 1-Year Est. Return

Renaissance Technologies's UPB Position: Q2 2026 in Review

Renaissance Technologies increased its Upstream Bio Inc (UPB) stake by 111% in Q2 2026, buying an estimated $580K and bringing the position to 131,300 shares worth $909K. The position accounts for ﹤0.01% of the portfolio, ranked #2351.

Renaissance Technologies first reported a position in UPB in Q4 2025 and has held it in 3 quarters since. 149 funds tracked by Wall St. Rank hold UPB as of Q2 2026.

  • Renaissance Technologies held 131,300 shares of Upstream Bio Inc worth $909K as of Q2 2026.
  • Renaissance Technologies bought 69,200 Upstream Bio Inc shares in Q2 2026, an estimated $580K.
  • Upstream Bio Inc made up ﹤0.01% of Renaissance Technologies's portfolio in Q2 2026, its #2351 holding.
  • Renaissance Technologies first reported a position in Upstream Bio Inc in Q4 2025 and has held it in 3 quarters since.
  • 149 funds tracked by Wall St. Rank held Upstream Bio Inc as of Q2 2026.

Based on Renaissance Technologies's 13F filing for Q2 2026, filed 13 Aug 2026.