UPB
Upstream Bio Inc
UPB
UPB
131 hedge funds and large institutions have $1.39B invested in Upstream Bio Inc in 2025 Q4 according to their latest regulatory filings, with 45 funds opening new positions, 42 increasing their positions, 33 reducing their positions, and 8 closing their positions.
New
Increased
Maintained
Reduced
Closed
more first-time investments, than exits
New positions opened: | Existing positions closed:
more call options, than puts
Call options by funds: $ | Put options by funds: $
more capital invested
Capital invested by funds: $ → $
more funds holding
Funds holding: →
27% more repeat investments, than reductions
Existing positions increased: 42 | Existing positions reduced: 33
20% more funds holding in top 10
Funds holding in top 10: 5 → 6 (+1)
12.22% more ownership
Funds ownership: 82.47% → 94.7% (+12%)
Holders
131
Holding in Top 10
6
Calls
$1.45M
Puts
$842K
Top Buyers
| 1 | +$38.2M | |
| 2 | +$38M | |
| 3 | +$19.2M | |
| 4 |
BlackRock
New York
|
+$18.4M |
| 5 |
VPC
Vestal Point Capital
New York
|
+$17.9M |
Top Sellers
| 1 | -$34.2M | |
| 2 | -$27.6M | |
| 3 | -$14.1M | |
| 4 |
Marshall Wace
London,
United Kingdom
|
-$13M |
| 5 |
Wellington Management Group
Boston,
Massachusetts
|
-$5.74M |
