SFM
UPB

Sphera Funds Management’s Upstream Bio Inc UPB Stock Holding History

Sphera Funds Management’s Portfolio UPB Stock Details UPB Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$3.22M Buy
+358,000
New +$6.44M 0.51% 63

Other funds holding UPB

Fidelity Investments
Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return
O
OrbiMed New York $5.05B AUM 125.28% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
DC
Decheng Capital Menlo Park, California $661M AUM 299.97% 1-Year Est. Return
ES
Enavate Sciences Menlo Park, California $352M AUM 220.14% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
YIH
Y-Intercept (HK) Hong Kong $5.05B AUM 17.89% 1-Year Est. Return
Federated Hermes
Federated Hermes Pittsburgh, Pennsylvania $61.5B AUM 30.7% 1-Year Est. Return
Geode Capital Management
Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return
Millennium Management
Millennium Management New York $240B AUM 35.51% 1-Year Est. Return

Sphera Funds Management's UPB Position: Q1 2026 in Review

Sphera Funds Management opened a new position in Upstream Bio Inc (UPB) in Q1 2026: 358,000 shares worth $3.22M. The stake represents 0.51% of the portfolio and ranks #63 among its holdings.

140 funds tracked by Wall St. Rank hold UPB as of Q1 2026.

  • Sphera Funds Management held 358,000 shares of Upstream Bio Inc worth $3.22M as of Q1 2026.
  • Upstream Bio Inc was a new Sphera Funds Management position in Q1 2026.
  • Upstream Bio Inc made up 0.51% of Sphera Funds Management's portfolio in Q1 2026, its #63 holding.
  • 140 funds tracked by Wall St. Rank held Upstream Bio Inc as of Q1 2026.

Based on Sphera Funds Management's 13F filing for Q1 2026, filed 15 May 2026.