SFM
UPB

Sphera Funds Management’s Upstream Bio Inc UPB Stock Holding History

Sphera Funds Management’s Portfolio UPB Stock Details UPB Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$1.52M Sell
219,700
-138,300
-39% -$1.16M 0.2% 93
2026
Q1 		$3.22M Buy
+358,000
New +$6.44M 0.51% 63

Other funds holding UPB

Fidelity Investments
Fidelity Investments Boston, Massachusetts $2.3T AUM 54.33% 1-Year Est. Return
O
OrbiMed New York $5.4B AUM 163.13% 1-Year Est. Return
Norges Bank
Norges Bank Oslo, Norway $1T AUM
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
DC
Decheng Capital Menlo Park, California $732M AUM 275.56% 1-Year Est. Return
ES
Enavate Sciences Menlo Park, California $345M AUM 134.64% 1-Year Est. Return
Vanguard Capital Management
Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM
Millennium Management
Millennium Management New York $276B AUM 44.8% 1-Year Est. Return
D.E. Shaw & Co
D.E. Shaw & Co New York $210B AUM 57.28% 1-Year Est. Return
JP Morgan Chase
JP Morgan Chase New York $1.81T AUM 41.13% 1-Year Est. Return

Sphera Funds Management's UPB Position: Q2 2026 in Review

Sphera Funds Management reduced its Upstream Bio Inc (UPB) stake by 39% in Q2 2026, selling an estimated $1.16M and leaving 219,700 shares worth $1.52M. The position accounts for 0.2% of the portfolio, ranked #93.

Sphera Funds Management first reported a position in UPB in Q1 2026 and has held it in 2 quarters since. The position peaked at $3.22M in Q1 2026. 149 funds tracked by Wall St. Rank hold UPB as of Q2 2026.

  • Sphera Funds Management held 219,700 shares of Upstream Bio Inc worth $1.52M as of Q2 2026.
  • Sphera Funds Management sold 138,300 Upstream Bio Inc shares in Q2 2026, an estimated $1.16M.
  • Upstream Bio Inc made up 0.2% of Sphera Funds Management's portfolio in Q2 2026, its #93 holding.
  • Sphera Funds Management first reported a position in Upstream Bio Inc in Q1 2026 and has held it in 2 quarters since.
  • Sphera Funds Management's Upstream Bio Inc position peaked at $3.22M in Q1 2026.
  • 149 funds tracked by Wall St. Rank held Upstream Bio Inc as of Q2 2026.

Based on Sphera Funds Management's 13F filing for Q2 2026, filed 14 Aug 2026.