American Century Companies
UPB

American Century Companies’s Upstream Bio Inc UPB Stock Holding History

American Century Companies’s Portfolio UPB Stock Details UPB Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$541K Sell
78,194
-9,430
-11% -$79K ﹤0.01% 2571
2026
Q1 		$789K Sell
87,624
-132
-0.2% -$2.38K ﹤0.01% 2395
2025
Q4 		$2.38M Buy
87,756
+16,216
+23% +$404K ﹤0.01% 2026
2025
Q3 		$1.35M Buy
71,540
+49,178
+220% +$764K ﹤0.01% 2201
2025
Q2 		$246K Buy
+22,362
New +$207K ﹤0.01% 2705

Other funds holding UPB

Fidelity Investments
Fidelity Investments Boston, Massachusetts $2.3T AUM 54.33% 1-Year Est. Return
O
OrbiMed New York $5.4B AUM 163.13% 1-Year Est. Return
Norges Bank
Norges Bank Oslo, Norway $1T AUM
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
DC
Decheng Capital Menlo Park, California $732M AUM 275.56% 1-Year Est. Return
ES
Enavate Sciences Menlo Park, California $345M AUM 134.64% 1-Year Est. Return
Vanguard Capital Management
Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM
Millennium Management
Millennium Management New York $276B AUM 44.8% 1-Year Est. Return
D.E. Shaw & Co
D.E. Shaw & Co New York $210B AUM 57.28% 1-Year Est. Return
JP Morgan Chase
JP Morgan Chase New York $1.81T AUM 41.13% 1-Year Est. Return

American Century Companies's UPB Position: Q2 2026 in Review

American Century Companies reduced its Upstream Bio Inc (UPB) stake by 11% in Q2 2026, selling an estimated $79K and leaving 78,194 shares worth $541K. The position accounts for ﹤0.01% of the portfolio, ranked #2571.

American Century Companies first reported a position in UPB in Q2 2025 and has held it in 5 quarters since. The position peaked at $2.38M in Q4 2025. 148 funds tracked by Wall St. Rank hold UPB as of Q2 2026.

  • American Century Companies held 78,194 shares of Upstream Bio Inc worth $541K as of Q2 2026.
  • American Century Companies sold 9,430 Upstream Bio Inc shares in Q2 2026, an estimated $79K.
  • Upstream Bio Inc made up ﹤0.01% of American Century Companies's portfolio in Q2 2026, its #2571 holding.
  • American Century Companies first reported a position in Upstream Bio Inc in Q2 2025 and has held it in 5 quarters since.
  • American Century Companies's Upstream Bio Inc position peaked at $2.38M in Q4 2025.
  • 148 funds tracked by Wall St. Rank held Upstream Bio Inc as of Q2 2026.

Based on American Century Companies's 13F filing for Q2 2026, filed 12 Aug 2026.