American Century Companies
UPB

American Century Companies’s Upstream Bio Inc UPB Stock Holding History

American Century Companies’s Portfolio UPB Stock Details UPB Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$789K Sell
87,624
-132
-0.2% -$2.38K ﹤0.01% 2395
2025
Q4 		$2.38M Buy
87,756
+16,216
+23% +$404K ﹤0.01% 2026
2025
Q3 		$1.35M Buy
71,540
+49,178
+220% +$764K ﹤0.01% 2201
2025
Q2 		$246K Buy
+22,362
New +$207K ﹤0.01% 2705

Other funds holding UPB

Fidelity Investments
Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return
O
OrbiMed New York $5.05B AUM 125.28% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
DC
Decheng Capital Menlo Park, California $661M AUM 299.97% 1-Year Est. Return
ES
Enavate Sciences Menlo Park, California $352M AUM 220.14% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
YIH
Y-Intercept (HK) Hong Kong $5.05B AUM 17.89% 1-Year Est. Return
Federated Hermes
Federated Hermes Pittsburgh, Pennsylvania $61.5B AUM 30.7% 1-Year Est. Return
Geode Capital Management
Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return
Millennium Management
Millennium Management New York $240B AUM 35.51% 1-Year Est. Return

American Century Companies's UPB Position: Q1 2026 in Review

American Century Companies reduced its Upstream Bio Inc (UPB) stake by 0.15% in Q1 2026, selling an estimated $2.38K and leaving 87,624 shares worth $789K. The position accounts for ﹤0.01% of the portfolio, ranked #2395.

American Century Companies first reported a position in UPB in Q2 2025 and has held it in 4 quarters since. The position peaked at $2.38M in Q4 2025. 140 funds tracked by Wall St. Rank hold UPB as of Q1 2026.

  • American Century Companies held 87,624 shares of Upstream Bio Inc worth $789K as of Q1 2026.
  • American Century Companies sold 132 Upstream Bio Inc shares in Q1 2026, an estimated $2.38K.
  • Upstream Bio Inc made up ﹤0.01% of American Century Companies's portfolio in Q1 2026, its #2395 holding.
  • American Century Companies first reported a position in Upstream Bio Inc in Q2 2025 and has held it in 4 quarters since.
  • American Century Companies's Upstream Bio Inc position peaked at $2.38M in Q4 2025.
  • 140 funds tracked by Wall St. Rank held Upstream Bio Inc as of Q1 2026.

Based on American Century Companies's 13F filing for Q1 2026, filed 15 May 2026.