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SYRS

Syros Pharmaceuticals, Inc. Common Stock
SYRS

Delisted

SYRS was delisted on the 19th of March, 2025.

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70 hedge funds and large institutions have $105M invested in Syros Pharmaceuticals, Inc. Common Stock in 2024 Q2 according to their latest regulatory filings, with 12 funds opening new positions, 19 increasing their positions, 11 reducing their positions, and 17 closing their positions.

New
Increased
Maintained
Reduced
Closed

747% more call options, than puts

Call options by funds: $144K | Put options by funds: $17K

73% more repeat investments, than reductions

Existing positions increased: 19 | Existing positions reduced: 11

0% more funds holding in top 10

Funds holding in top 10: 2 → 2 (0)

6% less capital invested

Capital invested by funds: $112M → $105M (-$6.72M)

7% less funds holding

Funds holding: 75 → 70 (-5)

29% less first-time investments, than exits

New positions opened: 12 | Existing positions closed: 17

Holders
70
Holders Change
-5
Holders Change %
-6.67%
% of All Funds
1.01%
Holding in Top 10
2
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.03%
New
12
Increased
19
Reduced
11
Closed
17
Calls
$144K
Puts
$17K
Net Calls
+$127K
Net Calls Change
-$32K

Top Buyers

Rank Fund Capital Flow
1
EAM
Exome Asset Management
New York
+$836K
2
ECM
ExodusPoint Capital Management
New York
+$571K
3
UOC
UBS O'Connor
Illinois
+$542K
4
OM
Opaleye Management
Massachusetts
+$409K
5
PCM
Prelude Capital Management
New York
+$212K

Top Sellers

Rank Fund Capital Flow
1
DMKJ
David M. Knott Jr
-$1.25M
2
Millennium Management
Millennium Management
New York
-$1.04M
3
Goldman Sachs
Goldman Sachs
New York
-$968K
4
Assenagon Asset Management
Assenagon Asset Management
Luxembourg
-$810K
5
Jane Street
Jane Street
New York
-$701K
Name Holding Trade Value Shares
Change 		Change in
Stake
State Street
26
State Street
Massachusetts
$358K +$57.8K +11,000 +19%
Millennium Management
27
Millennium Management
New York
$325K -$1.04M -198,069 -76%
LCP
28
LGT Capital Partners
Switzerland
$284K – – –
BCM
29
Bridgeway Capital Management
Texas
$266K – – –
Northern Trust
30
Northern Trust
Illinois
$211K +$20.6K +3,915 +11%
PCM
31
Prelude Capital Management
New York
$208K +$212K +40,297 New
Two Sigma Investments
32
Two Sigma Investments
New York
$208K -$147K -28,017 -41%
1CM
33
1492 Capital Management
Wisconsin
$202K +$92K +17,500 +80%
Jane Street
34
Jane Street
New York
$202K -$701K -133,336 -77%
SCM
35
Superstring Capital Management
New York
$195K +$199K +37,789 New
Acadian Asset Management
36
Acadian Asset Management
Massachusetts
$178K +$91.5K +17,416 +101%
Susquehanna International Group
37
Susquehanna International Group
Pennsylvania
$155K +$158K +30,005 New
Qube Research & Technologies (QRT)
38
Qube Research & Technologies (QRT)
United Kingdom
$145K -$577K -109,722 -80%
Citadel Advisors
39
Citadel Advisors
Florida
$137K +$140K +26,622 New
T. Rowe Price Associates
40
T. Rowe Price Associates
Maryland
$117K – – –
UBS Group
41
UBS Group
Switzerland
$111K +$113K +21,532 +102,533%
C
42
Certuity
Florida
$109K +$111K +21,202 New
CGL
43
Clarius Group LLC
Washington
$96.1K – – –
Bank of America
44
Bank of America
North Carolina
$93.5K -$82.1K -15,618 -46%
Assenagon Asset Management
45
Assenagon Asset Management
Luxembourg
$81.9K -$810K -154,126 -91%
HighTower Advisors
46
HighTower Advisors
Illinois
$79K +$2.27K +431 +3%
Simplex Trading
47
Simplex Trading
Illinois
$72K +$72.8K +13,859 +5,974%
Corient Private Wealth
48
Corient Private Wealth
Florida
$61.9K – – –
IWC
49
Integrated Wealth Concepts
Massachusetts
$51.6K – – –
Morgan Stanley
50
Morgan Stanley
New York
$50K -$40.8K -7,762 -44%
1
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SYRS Hedge Fund Activity: Q2 2024 in Review

70 of the 6,925 institutional investors tracked by Wall St. Rank reported a position in Syros Pharmaceuticals, Inc. Common Stock (SYRS) for Q2 2024, worth a combined $105M — down 6% from $112M a quarter earlier.

Sellers outnumbered buyers: 17 funds closed out of SYRS and 12 opened new positions — a net loss of 5 holders — while 11 trimmed existing stakes and 19 added.

The largest buyer was Exome Asset Management, opening a new position worth an estimated $836K. The largest seller was David M. Knott Jr, exiting entirely with an estimated $1.25M sold.

  • 70 institutional investors held Syros Pharmaceuticals, Inc. Common Stock (SYRS) as of Q2 2024, down from 75 in Q1 2024.
  • Funds reported $105M of Syros Pharmaceuticals, Inc. Common Stock stock for Q2 2024, down 6% quarter-over-quarter.
  • 12 funds opened new Syros Pharmaceuticals, Inc. Common Stock positions in Q2 2024 and 17 closed out, a net change of -5 holders.
  • The largest Syros Pharmaceuticals, Inc. Common Stock buyer in Q2 2024 was Exome Asset Management, an estimated $836K added.
  • The largest Syros Pharmaceuticals, Inc. Common Stock seller in Q2 2024 was David M. Knott Jr, an estimated $1.25M sold.

Based on aggregated 13F filings for Q2 2024.