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SYRS

Syros Pharmaceuticals, Inc. Common Stock

Delisted

SYRS was delisted on the 19th of March, 2025.

90 hedge funds and large institutions have $166M invested in Syros Pharmaceuticals, Inc. Common Stock in 2021 Q4 according to their latest regulatory filings, with 12 funds opening new positions, 31 increasing their positions, 31 reducing their positions, and 22 closing their positions.

New
Increased
Maintained
Reduced
Closed

0% more funds holding in top 10

Funds holding in top 10: 11 (0)

0% more repeat investments, than reductions

Existing positions increased: 31 | Existing positions reduced: 31

10% less funds holding

Funds holding: 10090 (-10)

26% less capital invested

Capital invested by funds: $223M → $166M (-$57.1M)

45% less first-time investments, than exits

New positions opened: 12 | Existing positions closed: 22

66% less call options, than puts

Call options by funds: $85K | Put options by funds: $249K

Holders
90
Holders Change
-10
Holders Change %
-10%
% of All Funds
1.38%
Holding in Top 10
1
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
0.02%
New
12
Increased
31
Reduced
31
Closed
22
Calls
$85K
Puts
$249K
Net Calls
-$164K
Net Calls Change
+$1.16M
Name Holding Trade Value Shares
Change
Change in
Stake
BCM
26
Bridgeway Capital Management
Texas
$554K +$688K +17,000 New
Susquehanna International Group
27
Susquehanna International Group
Pennsylvania
$541K -$191K -4,723 -22%
Federated Hermes
28
Federated Hermes
Pennsylvania
$538K +$668K +16,492 New
Charles Schwab
29
Charles Schwab
California
$466K -$243 -6 -0%
Connor, Clark & Lunn Investment Management (CC&L)
30
Connor, Clark & Lunn Investment Management (CC&L)
British Columbia, Canada
$387K +$62K +1,532 +15%
Jacobs Levy Equity Management
31
Jacobs Levy Equity Management
New Jersey
$337K +$6.72K +166 +2%
T. Rowe Price Associates
32
T. Rowe Price Associates
Maryland
$330K +$211K +5,220 +106%
Millennium Management
33
Millennium Management
New York
$301K -$907K -22,408 -71%
Two Sigma Advisers
34
Two Sigma Advisers
New York
$295K -$332K -8,210 -48%
State Board of Administration of Florida Retirement System
35
State Board of Administration of Florida Retirement System
Florida
$256K
LPL Financial
36
LPL Financial
California
$228K +$92.9K +2,294 +49%
Barclays
37
Barclays
United Kingdom
$228K +$101K +2,502 +56%
Morgan Stanley
38
Morgan Stanley
New York
$227K -$646K -15,959 -70%
CANY
39
Caxton Associates (New York)
New York
$218K +$271K +6,683 New
RhumbLine Advisers
40
RhumbLine Advisers
Massachusetts
$217K -$445 -11 -0.2%
Citadel Advisors
41
Citadel Advisors
Florida
$206K -$25K -618 -9%
Franklin Resources
42
Franklin Resources
California
$205K -$4.05K -100 -2%
AllianceBernstein
43
AllianceBernstein
Tennessee
$171K -$13.4K -330 -6%
Two Sigma Investments
44
Two Sigma Investments
New York
$159K -$173K -4,261 -47%
Ensign Peak Advisors
45
Ensign Peak Advisors
Utah
$147K -$223K -5,500 -55%
Nomura Holdings
46
Nomura Holdings
Japan
$142K +$176K +4,345 New
Bank of America
47
Bank of America
North Carolina
$139K +$46K +1,136 +36%
Deutsche Bank
48
Deutsche Bank
Germany
$120K -$93.5K -2,309 -39%
New York State Common Retirement Fund
49
New York State Common Retirement Fund
New York
$111K -$810 -20 -0.6%
California State Teachers Retirement System (CalSTRS)
50
California State Teachers Retirement System (CalSTRS)
California
$101K

SYRS Hedge Fund Activity: Q4 2021 in Review

90 of the 6,499 institutional investors tracked by Wall St. Rank reported a position in Syros Pharmaceuticals, Inc. Common Stock (SYRS) for Q4 2021, worth a combined $166M — down 26% from $223M a quarter earlier.

Sellers outnumbered buyers: 22 funds closed out of SYRS and 12 opened new positions — a net loss of 10 holders — while 31 trimmed existing stakes and 31 added.

The largest buyer was Artal Group, adding an estimated $4.05M. The largest seller was Millennium Management, cutting an estimated $907K.

  • 90 institutional investors held Syros Pharmaceuticals, Inc. Common Stock (SYRS) as of Q4 2021, down from 100 in Q3 2021.
  • Funds reported $166M of Syros Pharmaceuticals, Inc. Common Stock stock for Q4 2021, down 26% quarter-over-quarter.
  • 12 funds opened new Syros Pharmaceuticals, Inc. Common Stock positions in Q4 2021 and 22 closed out, a net change of -10 holders.
  • The largest Syros Pharmaceuticals, Inc. Common Stock buyer in Q4 2021 was Artal Group, an estimated $4.05M added.
  • The largest Syros Pharmaceuticals, Inc. Common Stock seller in Q4 2021 was Millennium Management, an estimated $907K sold.

Based on aggregated 13F filings for Q4 2021.