|
1
|
EcoR1 Capital
San Francisco,
California
|
$154M
|
+$99.1M
|
+3,928,300
|
+122%
|
|
|
2
|
Tang Capital Management
San Diego,
California
|
$56.6M
|
–
|
–
|
–
|
|
|
3
|
Vanguard Group
Malvern,
Pennsylvania
|
$50.1M
|
+$2.62M
|
+103,938
|
+5%
|
|
|
4
|
|
$45.2M
|
+$4.75M
|
+188,304
|
+10%
|
|
|
5
|
State Street
Boston,
Massachusetts
|
$38M
|
+$13.8M
|
+545,939
|
+45%
|
|
|
6
|
Boxer Capital
San Diego,
California
|
$28M
|
–
|
–
|
–
|
|
|
7
|
BVF Inc
San Francisco,
California
|
$25.6M
|
+$30M
|
+1,189,500
|
New
|
|
|
8
|
Federated Hermes
Pittsburgh,
Pennsylvania
|
$24.4M
|
-$4.72M
|
-187,016
|
-14%
|
|
|
9
|
Frazier Management
Seattle,
Washington
|
$19.4M
|
–
|
–
|
–
|
|
|
10
|
Dimensional Fund Advisors
Austin,
Texas
|
$14.1M
|
+$1.75M
|
+69,160
|
+12%
|
|
|
11
|
Cormorant Asset Management
Boston,
Massachusetts
|
$14M
|
–
|
–
|
–
|
|
|
12
|
Rock Springs Capital Management
Baltimore,
Maryland
|
$11.5M
|
+$5.7M
|
+225,819
|
+73%
|
|
|
13
|
Palo Alto Investors
Palo Alto,
California
|
$9.41M
|
+$512K
|
+20,300
|
+5%
|
|
|
14
|
Woodline Partners
San Francisco,
California
|
$9.24M
|
+$10.8M
|
+428,847
|
New
|
|
|
15
|
Baker Bros. Advisors
New York
|
$9.21M
|
–
|
–
|
–
|
|
|
16
|
|
$9.2M
|
+$2.1M
|
+83,241
|
+24%
|
|
|
17
|
Two Sigma Advisers
New York
|
$8.94M
|
+$752K
|
+29,800
|
+8%
|
|
|
18
|
Geode Capital Management
Boston,
Massachusetts
|
$8.5M
|
+$949K
|
+37,601
|
+11%
|
|
|
19
|
Nuveen
Charlotte,
North Carolina
|
$8.14M
|
+$5.56M
|
+220,383
|
+140%
|
|
|
20
|
|
$6.96M
|
+$543K
|
+21,524
|
+7%
|
|
|
21
|
|
$6.37M
|
-$6.8M
|
-269,331
|
-48%
|
|
|
22
|
Two Sigma Investments
New York
|
$6.18M
|
-$615K
|
-24,347
|
-8%
|
|
|
23
|
Northern Trust
Chicago,
Illinois
|
$5.06M
|
-$636K
|
-25,199
|
-10%
|
|
|
24
|
Renaissance Technologies
New York
|
$4.97M
|
+$2.43M
|
+96,182
|
+71%
|
|
|
25
|
|
$3.44M
|
+$3.48M
|
+137,996
|
+641%
|
|
