|
1
|
Frazier Management
Seattle,
Washington
|
$384M
|
–
|
–
|
–
|
|
|
2
|
Fidelity Investments
Boston,
Massachusetts
|
$372M
|
+$27.8M
|
+246,647
|
+7%
|
|
|
3
|
Janus Henderson Group
London,
|
$203M
|
+$56.6M
|
+502,086
|
+35%
|
|
|
4
|
|
$148M
|
+$3.36M
|
+29,812
|
+2%
|
|
|
5
|
Adage Capital Partners
Boston,
Massachusetts
|
$143M
|
+$14.4M
|
+127,500
|
+10%
|
|
|
6
|
Vanguard Group
Malvern,
Pennsylvania
|
$131M
|
+$38.8M
|
+344,051
|
+38%
|
|
|
7
|
Cormorant Asset Management
Boston,
Massachusetts
|
$115M
|
-$16.6M
|
-147,463
|
-12%
|
|
|
8
|
OppenheimerFunds
New York
|
$109M
|
-$1.38M
|
-12,267
|
-1%
|
|
|
9
|
State Street
Boston,
Massachusetts
|
$99.7M
|
+$35.2M
|
+311,916
|
+48%
|
|
|
10
|
Deerfield Management
New York
|
$82.7M
|
-$2.05M
|
-18,146
|
-2%
|
|
|
11
|
Redmile Group
San Francisco,
California
|
$54.4M
|
+$33.1M
|
+293,300
|
+128%
|
|
|
12
|
Viking Global Investors
Stamford,
Connecticut
|
$47.9M
|
+$51.8M
|
+459,950
|
New
|
|
|
13
|
Federated Hermes
Pittsburgh,
Pennsylvania
|
$45.9M
|
+$11.5K
|
+102
|
+0%
|
|
|
14
|
BVF Inc
San Francisco,
California
|
$40.2M
|
-$23.5M
|
-208,332
|
-35%
|
|
|
15
|
Marshall Wace North America
New York
|
$34.2M
|
+$15.9M
|
+141,173
|
+75%
|
|
|
16
|
Millennium Management
New York
|
$32.2M
|
+$14.7M
|
+130,686
|
+73%
|
|
|
17
|
Capital World Investors
Los Angeles,
California
|
$31.6M
|
+$34.3M
|
+304,000
|
New
|
|
|
18
|
Citadel Advisors
Miami,
Florida
|
$31.3M
|
-$22.1M
|
-196,202
|
-39%
|
|
|
19
|
Perceptive Advisors
New York
|
$24.7M
|
-$58.5M
|
-519,106
|
-69%
|
|
|
20
|
Franklin Resources
San Mateo,
California
|
$21.7M
|
-$13.2M
|
-117,300
|
-36%
|
|
|
21
|
T. Rowe Price Associates
Baltimore,
Maryland
|
$21M
|
+$10.4M
|
+92,383
|
+85%
|
|
|
22
|
Northern Trust
Chicago,
Illinois
|
$20.6M
|
+$920K
|
+8,164
|
+4%
|
|
|
23
|
Deutsche Bank
Frankfurt Am Main Ge,
Germany
|
$20M
|
-$72.7K
|
-645
|
-0.3%
|
|
|
24
|
|
$19.8M
|
+$4.51M
|
+40,000
|
+27%
|
|
|
25
|
VHCP Management II
New York
|
$18.8M
|
-$11.5M
|
-101,600
|
-36%
|
|
