|
1
|
Frazier Management
Seattle,
Washington
|
$372M
|
–
|
–
|
–
|
|
|
2
|
Fidelity Investments
Boston,
Massachusetts
|
$335M
|
+$83.3M
|
+1,131,923
|
+52%
|
|
|
3
|
Janus Henderson Group
London,
|
$146M
|
+$106M
|
+1,445,796
|
New
|
|
|
4
|
|
$140M
|
+$52.3M
|
+710,574
|
+104%
|
|
|
5
|
Cormorant Asset Management
Boston,
Massachusetts
|
$126M
|
+$18.5M
|
+251,485
|
+25%
|
|
|
6
|
Adage Capital Partners
Boston,
Massachusetts
|
$126M
|
+$2.28M
|
+31,014
|
+3%
|
|
|
7
|
OppenheimerFunds
New York
|
$107M
|
+$78M
|
+1,059,381
|
New
|
|
|
8
|
Vanguard Group
Malvern,
Pennsylvania
|
$91.7M
|
+$35.7M
|
+484,584
|
+114%
|
|
|
9
|
Deerfield Management
New York
|
$81.8M
|
-$873K
|
-11,854
|
-1%
|
|
|
10
|
Perceptive Advisors
New York
|
$76.2M
|
-$16.6M
|
-225,882
|
-23%
|
|
|
11
|
State Street
Boston,
Massachusetts
|
$65M
|
+$38.1M
|
+517,815
|
+405%
|
|
|
12
|
BVF Inc
San Francisco,
California
|
$59.9M
|
-$57.8M
|
-784,737
|
-57%
|
|
|
13
|
Farallon Capital Management
San Francisco,
California
|
$56.5M
|
+$23.2M
|
+315,000
|
+128%
|
|
|
14
|
Citadel Advisors
Miami,
Florida
|
$50M
|
-$6.41M
|
-87,080
|
-15%
|
|
|
15
|
Federated Hermes
Pittsburgh,
Pennsylvania
|
$44.4M
|
+$20.2M
|
+274,128
|
+164%
|
|
|
16
|
PFM Health Sciences
San Francisco,
California
|
$42.9M
|
+$31.4M
|
+425,896
|
New
|
|
|
17
|
Franklin Resources
San Mateo,
California
|
$32.8M
|
+$3.42M
|
+46,400
|
+17%
|
|
|
18
|
|
$32.6M
|
+$22.7M
|
+307,782
|
+1,971%
|
|
|
19
|
VHCP Management II
New York
|
$28.5M
|
+$8.47M
|
+115,000
|
+69%
|
|
|
20
|
Redmile Group
San Francisco,
California
|
$23.1M
|
+$16.9M
|
+229,850
|
New
|
|
|
21
|
Deutsche Bank
Frankfurt Am Main Ge,
Germany
|
$19.4M
|
+$6.45M
|
+87,566
|
+84%
|
|
|
22
|
Northern Trust
Chicago,
Illinois
|
$19.1M
|
+$4.67M
|
+63,500
|
+50%
|
|
|
23
|
Marshall Wace North America
New York
|
$18.9M
|
+$9.94M
|
+135,014
|
+256%
|
|
|
24
|
Baker Bros. Advisors
New York
|
$18.3M
|
+$5.15M
|
+70,000
|
+63%
|
|
|
25
|
Millennium Management
New York
|
$18M
|
-$10.8M
|
-147,117
|
-45%
|
|
