|
1
|
Frazier Management
Seattle,
Washington
|
$129M
|
–
|
–
|
–
|
|
|
2
|
Fidelity Investments
Boston,
Massachusetts
|
$76.6M
|
+$59.1M
|
+2,192,030
|
New
|
|
|
3
|
BVF Inc
San Francisco,
California
|
$48.2M
|
-$7.55M
|
-280,066
|
-17%
|
|
|
4
|
Adage Capital Partners
Boston,
Massachusetts
|
$42.6M
|
+$18.5M
|
+687,310
|
+129%
|
|
|
5
|
Novo Holdings A/S
Hellerup,
Denmark
|
$41.6M
|
-$49.7M
|
-1,842,900
|
-61%
|
|
|
6
|
Cormorant Asset Management
Boston,
Massachusetts
|
$35M
|
+$5.41M
|
+200,531
|
+25%
|
|
|
7
|
Perceptive Advisors
New York
|
$34.3M
|
+$809K
|
+30,000
|
+3%
|
|
|
8
|
Deerfield Management
New York
|
$28.8M
|
+$7.32M
|
+271,479
|
+49%
|
|
|
9
|
|
$23.9M
|
+$10.3M
|
+380,575
|
+126%
|
|
|
10
|
Citadel Advisors
Miami,
Florida
|
$20.4M
|
+$15.7M
|
+583,849
|
New
|
|
|
11
|
Vanguard Group
Malvern,
Pennsylvania
|
$14.9M
|
+$5.93M
|
+219,955
|
+107%
|
|
|
12
|
Millennium Management
New York
|
$11.4M
|
+$7.49M
|
+277,500
|
+573%
|
|
|
13
|
Franklin Resources
San Mateo,
California
|
$9.76M
|
–
|
–
|
–
|
|
|
14
|
Farallon Capital Management
San Francisco,
California
|
$8.6M
|
+$6.64M
|
+246,000
|
New
|
|
|
15
|
|
$6.36M
|
+$3.35M
|
+124,219
|
+210%
|
|
|
16
|
VHCP Management II
New York
|
$5.86M
|
+$4.52M
|
+167,550
|
New
|
|
|
17
|
Federated Hermes
Pittsburgh,
Pennsylvania
|
$5.84M
|
-$890K
|
-33,000
|
-17%
|
|
|
18
|
|
$5.24M
|
-$2.7M
|
-100,000
|
-40%
|
|
|
19
|
Rock Springs Capital Management
Baltimore,
Maryland
|
$5.24M
|
+$4.05M
|
+150,000
|
New
|
|
|
20
|
State Street
Boston,
Massachusetts
|
$4.47M
|
+$1.43M
|
+53,086
|
+71%
|
|
|
21
|
Northern Trust
Chicago,
Illinois
|
$4.41M
|
+$1.79M
|
+66,264
|
+110%
|
|
|
22
|
|
$4.29M
|
+$3.26M
|
+120,787
|
+6,522%
|
|
|
23
|
Spark Investment Management
New York
|
$4.24M
|
+$1.28M
|
+47,300
|
+64%
|
|
|
24
|
Baker Bros. Advisors
New York
|
$3.89M
|
-$157K
|
-5,825
|
-5%
|
|
|
25
|
|
$3.76M
|
+$2.59M
|
+95,994
|
+830%
|
|
