Jane Street
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Jane Street’s Karyopharm Therapeutics KPTI Stock Holding History

Jane Street’s Portfolio KPTI Stock Details KPTI Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$233K Buy
23,800
+9,400
+65% +$81.5K ﹤0.01% 9764
2026
Q1 		$80.2K Sell
14,400
-21,300
-60% -$162K ﹤0.01% 10743
2025
Q4 		$263K Buy
+35,700
New +$218K ﹤0.01% 9127
2023
Q3 		– Sell
-1,093
Closed -$29.4K – 9036
2023
Q2 		$29.4K Buy
1,093
+333
+44% +$14.3K ﹤0.01% 8313
2023
Q1 		$44.3K Buy
+760
New +$37.5K ﹤0.01% 8482
2022
Q4 		– Sell
-1,840
Closed -$151K – 9656
2022
Q3 		$151K Sell
1,840
-1,140
-38% -$85.2K ﹤0.01% 8394
2022
Q2 		$202K Sell
2,980
-3,347
-53% -$307K ﹤0.01% 8177
2022
Q1 		$699K Buy
6,327
+4,974
+368% +$620K ﹤0.01% 6851
2021
Q4 		$131K Sell
1,353
-140
-9% -$14K ﹤0.01% 9093
2021
Q3 		$130K Buy
1,493
+66
+5% +$6.85K ﹤0.01% 9148
2021
Q2 		$221K Sell
1,427
-1,500
-51% -$218K ﹤0.01% 8665
2021
Q1 		$462K Sell
2,927
-640
-18% -$135K ﹤0.01% 6945
2020
Q4 		$828K Buy
3,567
+1,280
+56% +$297K ﹤0.01% 4977
2020
Q3 		$501K Sell
2,287
-1,033
-31% -$253K ﹤0.01% 5152
2020
Q2 		$943K Buy
+3,320
New +$982K ﹤0.01% 4146

Other funds holding KPTI

RCM
RA Capital Management Boston, Massachusetts $11.5B AUM 168.77% 1-Year Est. Return
Adage Capital Partners
Adage Capital Partners Boston, Massachusetts $71.3B AUM 56.8% 1-Year Est. Return
ACA
Acorn Capital Advisors New York $366M AUM 474.6% 1-Year Est. Return
Goldman Sachs
Goldman Sachs New York $1.15T AUM 47.82% 1-Year Est. Return
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
Vanguard Capital Management
Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM
CCM
Catalio Capital Management New York $532M AUM 171.17% 1-Year Est. Return
APM
Avidity Partners Management Dallas, Texas $624M AUM 250.2% 1-Year Est. Return
T. Rowe Price Investment Management
T. Rowe Price Investment Management Baltimore, Maryland $153B AUM 38.14% 1-Year Est. Return
Two Sigma Investments
Two Sigma Investments New York $138B AUM 41.87% 1-Year Est. Return

Jane Street's KPTI Position: Q2 2026 in Review

Jane Street reduced its Karyopharm Therapeutics (KPTI) stake by 69% in Q2 2026, selling an estimated $631K and leaving 33,173 shares worth $324K. The position accounts for ﹤0.01% of the portfolio, ranked #9039.

Jane Street first reported a position in KPTI in Q2 2014 and has held it in 24 quarters since. The position peaked at $3.07M in Q1 2022. 96 funds tracked by Wall St. Rank hold KPTI as of Q2 2026.

  • Jane Street held 33,173 shares of Karyopharm Therapeutics worth $324K as of Q2 2026.
  • Jane Street sold 72,728 Karyopharm Therapeutics shares in Q2 2026, an estimated $631K.
  • Karyopharm Therapeutics made up ﹤0.01% of Jane Street's portfolio in Q2 2026, its #9039 holding.
  • Jane Street first reported a position in Karyopharm Therapeutics in Q2 2014 and has held it in 24 quarters since.
  • Jane Street's Karyopharm Therapeutics position peaked at $3.07M in Q1 2022.
  • 96 funds tracked by Wall St. Rank held Karyopharm Therapeutics as of Q2 2026.

Based on Jane Street's 13F filing for Q2 2026, filed 14 Aug 2026.