Jane Street
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Jane Street’s Karyopharm Therapeutics KPTI Stock Holding History

Jane Street’s Portfolio KPTI Stock Details KPTI Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$2.64M Buy
473,400
+453,300
+2,255% +$3.46M ﹤0.01% 4583
2025
Q4 		$148K Buy
20,100
+7,200
+56% +$44K ﹤0.01% 9941
2025
Q3 		$84.4K Buy
+12,900
New +$69.4K ﹤0.01% 10201
2023
Q2 		– Sell
-700
Closed -$40.8K – 9172
2023
Q1 		$40.8K Sell
700
-2,013
-74% -$99.4K ﹤0.01% 8505
2022
Q4 		$138K Sell
2,713
-167
-6% -$11.6K ﹤0.01% 7911
2022
Q3 		$236K Sell
2,880
-3,460
-55% -$258K ﹤0.01% 7928
2022
Q2 		$429K Sell
6,340
-6,307
-50% -$578K ﹤0.01% 7004
2022
Q1 		$1.4M Buy
12,647
+3,800
+43% +$474K ﹤0.01% 5431
2021
Q4 		$853K Buy
8,847
+7,340
+487% +$732K ﹤0.01% 6230
2021
Q3 		$132K Buy
1,507
+460
+44% +$47.8K ﹤0.01% 9141
2021
Q2 		$162K Buy
+1,047
New +$152K ﹤0.01% 8981
2021
Q1 		– Sell
-4,793
Closed -$1.11M – 9376
2020
Q4 		$1.11M Buy
4,793
+3,353
+233% +$777K ﹤0.01% 4478
2020
Q3 		$315K Sell
1,440
-7,280
-83% -$1.78M ﹤0.01% 5810
2020
Q2 		$2.48M Sell
8,720
-227
-3% -$67.1K ﹤0.01% 2765
2020
Q1 		$2.58M Buy
+8,947
New +$2.47M ﹤0.01% 1764

Other funds holding KPTI

CC
Commodore Capital New York $1.73B AUM 298.96% 1-Year Est. Return
RCM
RA Capital Management Boston, Massachusetts $9.44B AUM 157.3% 1-Year Est. Return
Adage Capital Partners
Adage Capital Partners Boston, Massachusetts $64.8B AUM 42.7% 1-Year Est. Return
T. Rowe Price Investment Management
T. Rowe Price Investment Management Baltimore, Maryland $145B AUM 22.78% 1-Year Est. Return
APM
Avidity Partners Management Dallas, Texas $936M AUM 195% 1-Year Est. Return
Goldman Sachs
Goldman Sachs New York $871B AUM 31.28% 1-Year Est. Return
CCM
Catalio Capital Management New York $479M AUM 140.7% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
IC
Ikarian Capital Dallas, Texas $1.23B AUM 600.17% 1-Year Est. Return
AAA
Affinity Asset Advisors New York $1.94B AUM 374.45% 1-Year Est. Return

Jane Street's KPTI Position: Q1 2026 in Review

Jane Street increased its Karyopharm Therapeutics (KPTI) stake by 198% in Q1 2026, buying an estimated $536K and bringing the position to 105,901 shares worth $590K. The position accounts for ﹤0.01% of the portfolio, ranked #7664.

Jane Street first reported a position in KPTI in Q2 2014 and has held it in 23 quarters since. The position peaked at $3.07M in Q1 2022. 77 funds tracked by Wall St. Rank hold KPTI as of Q1 2026.

  • Jane Street held 105,901 shares of Karyopharm Therapeutics worth $590K as of Q1 2026.
  • Jane Street bought 70,368 Karyopharm Therapeutics shares in Q1 2026, an estimated $536K.
  • Karyopharm Therapeutics made up ﹤0.01% of Jane Street's portfolio in Q1 2026, its #7664 holding.
  • Jane Street first reported a position in Karyopharm Therapeutics in Q2 2014 and has held it in 23 quarters since.
  • Jane Street's Karyopharm Therapeutics position peaked at $3.07M in Q1 2022.
  • 77 funds tracked by Wall St. Rank held Karyopharm Therapeutics as of Q1 2026.

Based on Jane Street's 13F filing for Q1 2026, filed 12 May 2026.