|
1
|
Fidelity Investments
Boston,
Massachusetts
|
$215M
|
-$50.5M
|
-1,736,375
|
-18%
|
|
|
2
|
Vanguard Group
Malvern,
Pennsylvania
|
$172M
|
+$28.3M
|
+971,634
|
+18%
|
|
|
3
|
TRV GP III
Boston,
Massachusetts
|
$152M
|
–
|
–
|
–
|
|
|
4
|
|
$140M
|
+$8.38M
|
+287,908
|
+6%
|
|
|
5
|
Wellington Management Group
Boston,
Massachusetts
|
$125M
|
-$30.3M
|
-1,041,946
|
-19%
|
|
|
6
|
Boxer Capital
San Diego,
California
|
$95.9M
|
–
|
–
|
–
|
|
|
7
|
Bellevue Group
Kuesnacht,
Switzerland
|
$95.2M
|
+$46.7M
|
+1,604,000
|
+86%
|
|
|
8
|
Column Group
San Francisco,
California
|
$92.1M
|
–
|
–
|
–
|
|
|
9
|
Cormorant Asset Management
Boston,
Massachusetts
|
$86.5M
|
-$5.63M
|
-193,466
|
-6%
|
|
|
10
|
State Street
Boston,
Massachusetts
|
$77.3M
|
+$13.4M
|
+460,582
|
+20%
|
|
|
11
|
|
$77M
|
+$14.4M
|
+495,000
|
+21%
|
|
|
12
|
Farallon Capital Management
San Francisco,
California
|
$75.7M
|
+$7.28M
|
+250,000
|
+10%
|
|
|
13
|
BVF Inc
San Francisco,
California
|
$68.4M
|
–
|
–
|
–
|
|
|
14
|
Deerfield Management
New York
|
$43.1M
|
–
|
–
|
–
|
|
|
15
|
TRV GP IV
Boston,
Massachusetts
|
$39.1M
|
–
|
–
|
–
|
|
|
16
|
|
$36.3M
|
-$1.95M
|
-66,891
|
-5%
|
|
|
17
|
Capital World Investors
Los Angeles,
California
|
$33.8M
|
–
|
–
|
–
|
|
|
18
|
Geode Capital Management
Boston,
Massachusetts
|
$29.7M
|
+$3.98M
|
+136,881
|
+14%
|
|
|
19
|
T. Rowe Price Associates
Baltimore,
Maryland
|
$28.1M
|
+$29.2M
|
+1,001,922
|
+5,590%
|
|
|
20
|
|
$26.8M
|
+$7.85M
|
+269,641
|
+38%
|
|
|
21
|
Ameriprise
Minneapolis,
Minnesota
|
$26.4M
|
+$633K
|
+21,742
|
+2%
|
|
|
22
|
Woodline Partners
San Francisco,
California
|
$23.9M
|
+$521K
|
+17,892
|
+2%
|
|
|
23
|
Ponoi II Management
San Francisco,
California
|
$18.8M
|
–
|
–
|
–
|
|
|
24
|
Ponoi Management
San Francisco,
California
|
$18.8M
|
–
|
–
|
–
|
|
|
25
|
Harvard Management Company
Boston,
Massachusetts
|
$18.4M
|
–
|
–
|
–
|
|
