|
1
|
|
$2.56B
|
+$363M
|
+2,483,084
|
+22%
|
|
|
2
|
Farallon Capital Management
San Francisco,
California
|
$2.54B
|
-$7.89M
|
-54,000
|
-0.4%
|
|
|
3
|
Fidelity Investments
Boston,
Massachusetts
|
$2.28B
|
+$546M
|
+3,736,108
|
+44%
|
|
|
4
|
Baker Bros. Advisors
New York
|
$2.14B
|
+$276M
|
+1,888,000
|
+20%
|
|
|
5
|
Darwin Global Management
St. Helier,
Jersey
|
$2.05B
|
+$1.23B
|
+8,418,804
|
+381%
|
|
|
6
|
|
$2.01B
|
+$1.57B
|
+10,736,145
|
New
|
|
|
7
|
Vanguard Capital Management
Malvern,
Pennsylvania
|
$1.7B
|
+$106M
|
+726,377
|
+9%
|
|
|
8
|
Vanguard Portfolio Management
Malvern,
Pennsylvania
|
$1.55B
|
+$116M
|
+792,232
|
+11%
|
|
|
9
|
Nextech Invest
Zurich,
Switzerland
|
$1.42B
|
–
|
–
|
–
|
|
|
10
|
Paradigm Biocapital Advisors
New York
|
$1.19B
|
-$43M
|
-294,380
|
-4%
|
|
|
11
|
UBS Group
Zurich,
Switzerland
|
$1.02B
|
+$155M
|
+1,061,573
|
+24%
|
|
|
12
|
State Street
Boston,
Massachusetts
|
$917M
|
+$72.2M
|
+494,389
|
+11%
|
|
|
13
|
Capital World Investors
Los Angeles,
California
|
$751M
|
+$585M
|
+4,008,244
|
New
|
|
|
14
|
Geode Capital Management
Boston,
Massachusetts
|
$737M
|
+$88.3M
|
+604,534
|
+18%
|
|
|
15
|
Wellington Management Group
Boston,
Massachusetts
|
$720M
|
-$319M
|
-2,184,404
|
-36%
|
|
|
16
|
|
$637M
|
+$438M
|
+2,996,673
|
+994%
|
|
|
17
|
BVF Inc
San Francisco,
California
|
$555M
|
+$15.8M
|
+108,378
|
+4%
|
|
|
18
|
Alphabet Inc
Mountain View,
California
|
$552M
|
-$50.5M
|
-345,906
|
-11%
|
|
|
19
|
|
$483M
|
–
|
–
|
–
|
|
|
20
|
Deerfield Management
New York
|
$448M
|
+$13.9M
|
+95,000
|
+4%
|
|
|
21
|
T. Rowe Price Associates
Baltimore,
Maryland
|
$448M
|
-$123M
|
-841,910
|
-26%
|
|
|
22
|
Avoro Capital Advisors
New York
|
$430M
|
-$6.93M
|
-47,444
|
-2%
|
|
|
23
|
|
$404M
|
+$315M
|
+2,157,479
|
New
|
|
|
24
|
|
$399M
|
-$7.65M
|
-52,399
|
-2%
|
|
|
25
|
Nearwater Capital Markets
Dublin 4, Dublin,
Ireland
|
$393M
|
+$207M
|
+1,419,000
|
+209%
|
|
