|
1
|
Fidelity Investments
Boston,
Massachusetts
|
$303M
|
-$45.3M
|
-1,297,986
|
-12%
|
|
|
2
|
Wellington Management Group
Boston,
Massachusetts
|
$177M
|
+$57.9M
|
+1,658,400
|
+42%
|
|
|
3
|
TRV GP III
Boston,
Massachusetts
|
$175M
|
–
|
–
|
–
|
|
|
4
|
Vanguard Group
Malvern,
Pennsylvania
|
$167M
|
+$14.6M
|
+418,302
|
+9%
|
|
|
5
|
|
$153M
|
+$34.5M
|
+987,056
|
+26%
|
|
|
6
|
Boxer Capital
San Diego,
California
|
$111M
|
–
|
–
|
–
|
|
|
7
|
Column Group
San Francisco,
California
|
$106M
|
-$8.13M
|
-233,007
|
-7%
|
|
|
8
|
Cormorant Asset Management
Boston,
Massachusetts
|
$106M
|
+$28.4M
|
+813,166
|
+32%
|
|
|
9
|
Farallon Capital Management
San Francisco,
California
|
$79.3M
|
+$31.1M
|
+890,270
|
+55%
|
|
|
10
|
BVF Inc
San Francisco,
California
|
$78.9M
|
-$16M
|
-458,000
|
-16%
|
|
|
11
|
State Street
Boston,
Massachusetts
|
$74.5M
|
+$19.9M
|
+570,410
|
+32%
|
|
|
12
|
|
$73.2M
|
+$16.1M
|
+460,465
|
+25%
|
|
|
13
|
Bellevue Group
Kuesnacht,
Switzerland
|
$58.9M
|
+$27.5M
|
+789,035
|
+74%
|
|
|
14
|
Deerfield Management
New York
|
$49.7M
|
+$4.5M
|
+129,000
|
+9%
|
|
|
15
|
TRV GP IV
Boston,
Massachusetts
|
$45.1M
|
–
|
–
|
–
|
|
|
16
|
|
$44M
|
+$5.21M
|
+149,364
|
+12%
|
|
|
17
|
Capital World Investors
Los Angeles,
California
|
$39M
|
–
|
–
|
–
|
|
|
18
|
Geode Capital Management
Boston,
Massachusetts
|
$30M
|
+$5.77M
|
+165,458
|
+21%
|
|
|
19
|
Ameriprise
Minneapolis,
Minnesota
|
$29.7M
|
+$18.1M
|
+517,478
|
+123%
|
|
|
20
|
Woodline Partners
San Francisco,
California
|
$27M
|
+$333K
|
+9,530
|
+1%
|
|
|
21
|
|
$22.4M
|
-$85K
|
-2,434
|
-0.3%
|
|
|
22
|
Ponoi II Management
San Francisco,
California
|
$21.7M
|
–
|
–
|
–
|
|
|
23
|
Ponoi Management
San Francisco,
California
|
$21.7M
|
–
|
–
|
–
|
|
|
24
|
Harvard Management Company
Boston,
Massachusetts
|
$21.3M
|
–
|
–
|
–
|
|
|
25
|
Northern Trust
Chicago,
Illinois
|
$18M
|
+$3.28M
|
+94,062
|
+20%
|
|
