|
1
|
Fidelity Investments
Boston,
Massachusetts
|
$130M
|
+$26.9M
|
+1,251,683
|
+24%
|
|
|
2
|
BVF Inc
San Francisco,
California
|
$86.2M
|
+$40.9M
|
+1,901,300
|
+80%
|
|
|
3
|
|
$73.6M
|
+$5.19M
|
+241,108
|
+7%
|
|
|
4
|
Consonance Capital Management
New York
|
$55M
|
+$7.75M
|
+360,000
|
+15%
|
|
|
5
|
|
$52.2M
|
+$2.92M
|
+135,734
|
+6%
|
|
|
6
|
Johnson & Johnson Innovation - JJDC
New Brunswick,
New Jersey
|
$49.4M
|
–
|
–
|
–
|
|
|
7
|
Farallon Capital Management
San Francisco,
California
|
$48.9M
|
-$6.99M
|
-325,000
|
-12%
|
|
|
8
|
Vanguard Group
Malvern,
Pennsylvania
|
$40.7M
|
+$10M
|
+465,178
|
+30%
|
|
|
9
|
State Street
Boston,
Massachusetts
|
$29.9M
|
+$7.1M
|
+329,763
|
+29%
|
|
|
10
|
Baker Bros. Advisors
New York
|
$29M
|
-$3.44M
|
-160,006
|
-10%
|
|
|
11
|
Deerfield Management
New York
|
$27.8M
|
+$4.3M
|
+200,000
|
+17%
|
|
|
12
|
Adage Capital Partners
Boston,
Massachusetts
|
$23.2M
|
-$29.5M
|
-1,370,555
|
-54%
|
|
|
13
|
Novo Holdings A/S
Hellerup,
Denmark
|
$17.5M
|
+$1.58M
|
+73,355
|
+9%
|
|
|
14
|
T. Rowe Price Associates
Baltimore,
Maryland
|
$17M
|
+$5.59M
|
+259,536
|
+44%
|
|
|
15
|
|
$14.2M
|
-$1.76M
|
-81,711
|
-10%
|
|
|
16
|
Dimensional Fund Advisors
Austin,
Texas
|
$13.1M
|
-$769K
|
-35,716
|
-5%
|
|
|
17
|
|
$11.1M
|
+$7.1M
|
+329,707
|
+148%
|
|
|
18
|
Point72 Asset Management
Stamford,
Connecticut
|
$11.1M
|
+$11.8M
|
+550,000
|
New
|
|
|
19
|
Geode Capital Management
Boston,
Massachusetts
|
$10.2M
|
+$1.49M
|
+69,187
|
+16%
|
|
|
20
|
Northern Trust
Chicago,
Illinois
|
$8.14M
|
+$413K
|
+19,200
|
+5%
|
|
|
21
|
Two Sigma Advisers
New York
|
$7.4M
|
+$260K
|
+12,100
|
+3%
|
|
|
22
|
Opaleye Management
Boston,
Massachusetts
|
$7.02M
|
+$5.6M
|
+260,000
|
New
|
|
|
23
|
Commodore Capital
New York
|
$7.01M
|
+$7.48M
|
+347,500
|
New
|
|
|
24
|
Citadel Advisors
Miami,
Florida
|
$6.87M
|
+$7.34M
|
+340,822
|
New
|
|
|
25
|
|
$6.79M
|
-$4.11M
|
-190,977
|
-36%
|
|
