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Protagonist Therapeutics
PTGX

Overview Fund Activity

270 hedge funds and large institutions have $3.92B invested in Protagonist Therapeutics in 2025 Q2 according to their latest regulatory filings, with 50 funds opening new positions, 119 increasing their positions, 76 reducing their positions, and 49 closing their positions.

Holders
270
Holders Change
-4
Holders Change %
-1.46%
% of All Funds
3.63%
Holding in Top 10
14
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.19%
New
50
Increased
119
Reduced
76
Closed
49
Calls
$11.6M
Puts
$15.9M
Net Calls
-$4.31M
Net Calls Change
-$23.5M

Top Buyers

1
UBS Group
1
UBS Group
Switzerland
$138M
2
CC
2
Commodore Capital
New York
$59.4M
3
Adage Capital Partners
3
Adage Capital Partners
Massachusetts
$60.4M
4
BI
4
BVF Inc
California
$177M
5
Holocene Advisors
5
Holocene Advisors
New York
$29.3M

Top Sellers

1
T. Rowe Price Associates
1
T. Rowe Price Associates
Maryland
$51.8M
2
Focus Partners Wealth
2
Focus Partners Wealth
Massachusetts
$0
3
NVCHI
3
New Vernon Capital Holdings II
New Jersey
$398K
4
AGP
4
Artia Global Partners
Florida
$1.27M
5
Qube Research & Technologies (QRT)
5
Qube Research & Technologies (QRT)
United Kingdom
$3.81M
Name Market Value Shares Shares
Change 		Shares
Change %
BlackRock
1
BlackRock
New York
$532M 9,630,341 -106,426 -1%
FCM
2
Farallon Capital Management
California
$341M 6,172,006 +65,000 +1%
RI
3
RTW Investments
New York
$318M 5,756,277 +36,862 +0.6%
Vanguard Group
4
Vanguard Group
Pennsylvania
$241M 4,358,595 +81,377 +2%
DTC
5
Deep Track Capital
Connecticut
$179M 3,245,899 +245,899 +8%
BI
6
BVF Inc
California
$177M 3,211,041 +636,026 +25%
State Street
7
State Street
Massachusetts
$177M 3,207,543 +500,924 +19%
UBS Group
8
UBS Group
Switzerland
$138M 2,501,251 +2,148,380 +609%
JJ
9
Johnson & Johnson
New Jersey
$136M 2,449,183 – –
Geode Capital Management
10
Geode Capital Management
Massachusetts
$79.8M 1,444,230 +20,671 +1%
Adage Capital Partners
11
Adage Capital Partners
Massachusetts
$60.4M 1,092,262 +748,758 +218%
CC
12
Commodore Capital
New York
$59.4M 1,075,000 +1,075,000 New
PA
13
Perceptive Advisors
New York
$59.4M 1,074,448 -16,823 -2%
Wellington Management Group
14
Wellington Management Group
Massachusetts
$57.4M 1,037,738 +50,368 +5%
ACM
15
ADAR1 Capital Management
Texas
$52.4M 948,069 +8,400 +0.9%
WP
16
Woodline Partners
California
$52.3M 946,884 +49,185 +5%
T. Rowe Price Associates
17
T. Rowe Price Associates
Maryland
$51.8M 936,703 -385,303 -29%
Morgan Stanley
18
Morgan Stanley
New York
$48M 868,963 +371,858 +75%
Bank of America
19
Bank of America
North Carolina
$47.1M 851,832 +380,087 +81%
JFG
20
Jefferies Financial Group
New York
$45.5M 824,019 +192,126 +30%
American Century Companies
21
American Century Companies
Missouri
$45M 813,995 +128,171 +19%
Goldman Sachs
22
Goldman Sachs
New York
$43M 777,307 +221,756 +40%
DCM
23
Driehaus Capital Management
Illinois
$41.9M 757,710 +522,637 +222%
Pictet Asset Management
24
Pictet Asset Management
Switzerland
$41.6M 751,977 +456,384 +154%
LCM
25
Lynx1 Capital Management
Puerto Rico
$40.5M 733,014 – –
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