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Protagonist Therapeutics
PTGX
PTGX
313 hedge funds and large institutions have $6.18B invested in Protagonist Therapeutics in 2025 Q4 according to their latest regulatory filings, with 82 funds opening new positions, 97 increasing their positions, 103 reducing their positions, and 39 closing their positions.
New
Increased
Maintained
Reduced
Closed
1,764% more call options, than puts
Call options by funds: $85.2M | Put options by funds: $4.57M
110% more first-time investments, than exits
New positions opened: 82 | Existing positions closed: 39
32% more capital invested
Capital invested by funds: $4.7B → $6.18B (+$1.48B)
30% more funds holding in top 10
Funds holding in top 10: 10 → 13 (+3)
14% more funds holding
Funds holding: 274 → 313 (+39)
0.49% less ownership
Funds ownership: 113.62% → 113.13% (-0.49%)
6% less repeat investments, than reductions
Existing positions increased: 97 | Existing positions reduced: 103
Holders
313
Holders Change
+39
Holders Change %
+14.23%
% of All Funds
3.81%
Holding in Top 10
13
Holding in Top 10 Change
+3
Holding in Top 10 Change %
+30%
% of All Funds
0.16%
New
82
Increased
97
Reduced
103
Closed
39
Calls
$85.2M
Puts
$4.57M
Net Calls
+$80.6M
Net Calls Change
+$71.8M
Top Buyers
| 1 |
Janus Henderson Group
London,
United Kingdom
|
+$127M |
| 2 |
Wellington Management Group
Boston,
Massachusetts
|
+$103M |
| 3 |
Vanguard Group
Malvern,
Pennsylvania
|
+$94.7M |
| 4 |
Citadel Advisors
Miami,
Florida
|
+$72.7M |
| 5 |
UBS Group
Zurich,
Switzerland
|
+$71.5M |
Top Sellers
| 1 |
BI
BVF Inc
San Francisco,
California
|
-$170M |
| 2 |
DTC
Deep Track Capital
Greenwich,
Connecticut
|
-$114M |
| 3 |
JFG
Jefferies Financial Group
New York
|
-$66.8M |
| 4 |
RI
RTW Investments
New York
|
-$57.1M |
| 5 |
CC
Commodore Capital
New York
|
-$47.1M |
