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Protagonist Therapeutics

317 hedge funds and large institutions have $8.3B invested in Protagonist Therapeutics in 2026 Q1 according to their latest regulatory filings, with 59 funds opening new positions, 110 increasing their positions, 102 reducing their positions, and 47 closing their positions.

New
Increased
Maintained
Reduced
Closed

225% more call options, than puts

Call options by funds: $36.2M | Put options by funds: $11.1M

34% more capital invested

Capital invested by funds: $6.18B → $8.3B (+$2.12B)

26% more first-time investments, than exits

New positions opened: 59 | Existing positions closed: 47

10.28% more ownership

Funds ownership: 113.13%123.41% (+10%)

1% more funds holding

Funds holding: 313317 (+4)

8% more repeat investments, than reductions

Existing positions increased: 110 | Existing positions reduced: 102

23% less funds holding in top 10

Funds holding in top 10: 1310 (-3)

Holders
317
Holders Change
+4
Holders Change %
+1.28%
% of All Funds
3.9%
Holding in Top 10
10
Holding in Top 10 Change
-3
Holding in Top 10 Change %
-23.08%
% of All Funds
0.12%
New
59
Increased
110
Reduced
102
Closed
47
Calls
$36.2M
Puts
$11.1M
Net Calls
+$25.1M
Net Calls Change
-$55.5M
Name Holding Trade Value Shares
Change
Change in
Stake
BlackRock
1
BlackRock
New York
$1.03B +$5.61M +63,370 +0.7%
FCM
2
Farallon Capital Management
California
$669M +$18.1M +204,900 +3%
UBS Group
3
UBS Group
Switzerland
$546M +$213M +2,407,775 +87%
RI
4
RTW Investments
New York
$533M
Wellington Management Group
5
Wellington Management Group
Massachusetts
$379M +$37.9M +428,221 +14%
VPM
6
Vanguard Portfolio Management
Pennsylvania
$367M +$308M +3,481,211 New
State Street
7
State Street
Massachusetts
$329M -$7.35M -82,980 -3%
Janus Henderson Group
8
Janus Henderson Group
United Kingdom
$305M +$21.4M +241,546 +9%
VCM
9
Vanguard Capital Management
Pennsylvania
$296M +$248M +2,805,896 New
JJ
10
Johnson & Johnson
New Jersey
$258M
Invesco
11
Invesco
Georgia
$228M +$52.8M +596,830 +38%
Geode Capital Management
12
Geode Capital Management
Massachusetts
$176M +$19.2M +216,443 +15%
T. Rowe Price Associates
13
T. Rowe Price Associates
Maryland
$176M +$23.4M +264,759 +19%
Citadel Advisors
14
Citadel Advisors
Florida
$164M +$37.6M +425,213 +38%
WP
15
Woodline Partners
California
$149M +$478K +5,401 +0.4%
Bank of America
16
Bank of America
North Carolina
$137M +$37.9M +427,854 +49%
PA
17
Perceptive Advisors
New York
$130M -$10.6M -119,546 -9%
Jennison Associates
18
Jennison Associates
New York
$113M +$65.6M +740,847 +224%
Morgan Stanley
19
Morgan Stanley
New York
$107M +$12.3M +139,198 +16%
ACM
20
ADAR1 Capital Management
Texas
$105M -$4.87M -55,049 -5%
HRCM
21
Hood River Capital Management
Florida
$87.4M +$73.4M +829,285 New
Goldman Sachs
22
Goldman Sachs
New York
$82.1M -$16.1M -182,204 -19%
DCM
23
Driehaus Capital Management
Illinois
$76M -$33.5M -378,242 -34%
Fidelity Investments
24
Fidelity Investments
Massachusetts
$69.8M +$10.8M +122,119 +23%
Marshall Wace
25
Marshall Wace
United Kingdom
$66.2M -$35.1M -396,850 -39%