|
1
|
EcoR1 Capital
San Francisco,
California
|
$278M
|
–
|
–
|
–
|
|
|
2
|
Vanguard Group
Malvern,
Pennsylvania
|
$260M
|
+$63.3M
|
+1,448,166
|
+30%
|
|
|
3
|
|
$227M
|
+$6.09M
|
+139,390
|
+3%
|
|
|
4
|
T. Rowe Price Associates
Baltimore,
Maryland
|
$180M
|
+$23.4M
|
+536,295
|
+14%
|
|
|
5
|
|
$136M
|
-$40M
|
-915,586
|
-22%
|
|
|
6
|
Avidity Partners Management
Dallas,
Texas
|
$123M
|
+$3.19K
|
+73
|
+0%
|
|
|
7
|
Paradigm Biocapital Advisors
New York
|
$108M
|
+$73.6M
|
+1,683,632
|
+181%
|
|
|
8
|
Bellevue Group
Kuesnacht,
Switzerland
|
$98.7M
|
-$5.11M
|
-116,931
|
-5%
|
|
|
9
|
Fidelity Investments
Boston,
Massachusetts
|
$98.6M
|
+$6.33M
|
+144,935
|
+6%
|
|
|
10
|
Citadel Advisors
Miami,
Florida
|
$94.1M
|
-$6.96M
|
-159,368
|
-7%
|
|
|
11
|
|
$70.2M
|
-$20.7M
|
-472,986
|
-22%
|
|
|
12
|
Nextech Invest
Zurich,
Switzerland
|
$58.1M
|
-$12.6M
|
-287,251
|
-17%
|
|
|
13
|
State Street
Boston,
Massachusetts
|
$57.1M
|
+$8.55M
|
+195,693
|
+16%
|
|
|
14
|
Geode Capital Management
Boston,
Massachusetts
|
$54.2M
|
+$8.33M
|
+190,689
|
+17%
|
|
|
15
|
New Leaf Venture Partners
New York
|
$53.2M
|
–
|
–
|
–
|
|
|
16
|
Commodore Capital
New York
|
$52.6M
|
+$12M
|
+275,000
|
+28%
|
|
|
17
|
Perceptive Advisors
New York
|
$51M
|
+$38.6M
|
+882,521
|
+249%
|
|
|
18
|
ArrowMark Colorado Holdings
Denver,
Colorado
|
$49.8M
|
-$15.9M
|
-364,327
|
-23%
|
|
|
19
|
|
$45.8M
|
+$10.1M
|
+231,060
|
+26%
|
|
|
20
|
|
$27.9M
|
-$785K
|
-17,970
|
-3%
|
|
|
21
|
Adage Capital Partners
Boston,
Massachusetts
|
$26M
|
-$6.97M
|
-159,485
|
-20%
|
|
|
22
|
|
$25.9M
|
–
|
–
|
–
|
|
|
23
|
Boxer Capital
San Diego,
California
|
$25.1M
|
–
|
–
|
–
|
|
|
24
|
|
$24.5M
|
+$11.6M
|
+264,944
|
+80%
|
|
|
25
|
Finepoint Capital
Boston,
Massachusetts
|
$22.3M
|
+$1.5M
|
+34,400
|
+7%
|
|
