|
1
|
Fidelity Investments
Boston,
Massachusetts
|
$194M
|
-$43.9M
|
-1,043,403
|
-16%
|
|
|
2
|
Avidity Partners Management
Dallas,
Texas
|
$169M
|
+$25.5M
|
+606,500
|
+14%
|
|
|
3
|
Vanguard Group
Malvern,
Pennsylvania
|
$152M
|
+$11.7M
|
+277,192
|
+7%
|
|
|
4
|
|
$149M
|
+$27.3M
|
+649,662
|
+18%
|
|
|
5
|
EcoR1 Capital
San Francisco,
California
|
$107M
|
–
|
–
|
–
|
|
|
6
|
T. Rowe Price Associates
Baltimore,
Maryland
|
$81M
|
+$7.92M
|
+188,362
|
+9%
|
|
|
7
|
Bellevue Group
Kuesnacht,
Switzerland
|
$73.6M
|
-$1.7M
|
-40,350
|
-2%
|
|
|
8
|
|
$67.3M
|
-$5.25M
|
-124,803
|
-6%
|
|
|
9
|
New Leaf Venture Partners
New York
|
$44.1M
|
–
|
–
|
–
|
|
|
10
|
ArrowMark Colorado Holdings
Denver,
Colorado
|
$40.9M
|
+$10.2M
|
+241,783
|
+25%
|
|
|
11
|
T. Rowe Price Investment Management
Baltimore,
Maryland
|
$39.4M
|
-$32.9K
|
-783
|
-0.1%
|
|
|
12
|
State Street
Boston,
Massachusetts
|
$36.6M
|
-$674K
|
-16,014
|
-1%
|
|
|
13
|
American Century Companies
Kansas City,
Missouri
|
$31.7M
|
+$6.25M
|
+148,560
|
+19%
|
|
|
14
|
Geode Capital Management
Boston,
Massachusetts
|
$31.3M
|
+$1.27M
|
+30,169
|
+3%
|
|
|
15
|
|
$25.7M
|
-$540K
|
-12,842
|
-2%
|
|
|
16
|
|
$24M
|
-$1.33M
|
-31,600
|
-4%
|
|
|
17
|
Aquilo Capital Management
San Francisco,
California
|
$23.1M
|
+$92.4K
|
+2,196
|
+0.3%
|
|
|
18
|
Citadel Advisors
Miami,
Florida
|
$20.9M
|
+$18.4M
|
+436,992
|
+251%
|
|
|
19
|
Wellington Management Group
Boston,
Massachusetts
|
$20.7M
|
-$3.65M
|
-86,692
|
-13%
|
|
|
20
|
Paradigm Biocapital Advisors
New York
|
$20.5M
|
+$13.3M
|
+315,822
|
+111%
|
|
|
21
|
Candriam SCA
Strassen, Luxembourg,
Luxembourg
|
$18.3M
|
+$619K
|
+14,710
|
+3%
|
|
|
22
|
Pictet Asset Management (Switzerland)
Geneva 73,
Switzerland
|
$16.6M
|
-$577K
|
-13,708
|
-3%
|
|
|
23
|
Gilder Gagnon Howe & Co
New York
|
$16M
|
-$9.05M
|
-215,142
|
-32%
|
|
|
24
|
Brown Advisory
Baltimore,
Maryland
|
$15.8M
|
+$2.25M
|
+53,453
|
+13%
|
|
|
25
|
Northern Trust
Chicago,
Illinois
|
$15.1M
|
+$111K
|
+2,629
|
+0.6%
|
|
