|
1
|
Fidelity Investments
Boston,
Massachusetts
|
$310M
|
+$8.4M
|
+167,390
|
+2%
|
|
|
2
|
Vanguard Group
Malvern,
Pennsylvania
|
$171M
|
+$1.99M
|
+39,607
|
+1%
|
|
|
3
|
|
$155M
|
+$7.52M
|
+149,910
|
+4%
|
|
|
4
|
Avidity Partners Management
Dallas,
Texas
|
$141M
|
+$22.1M
|
+440,323
|
+15%
|
|
|
5
|
T. Rowe Price Associates
Baltimore,
Maryland
|
$138M
|
+$8.07M
|
+160,860
|
+5%
|
|
|
6
|
EcoR1 Capital
San Francisco,
California
|
$131M
|
+$81.3M
|
+1,619,371
|
+108%
|
|
|
7
|
|
$90.9M
|
+$14.1M
|
+280,691
|
+15%
|
|
|
8
|
Bellevue Group
Kuesnacht,
Switzerland
|
$89.4M
|
-$2.76M
|
-54,977
|
-3%
|
|
|
9
|
Wellington Management Group
Boston,
Massachusetts
|
$60.4M
|
+$33M
|
+657,500
|
+85%
|
|
|
10
|
New Leaf Venture Partners
New York
|
$54.3M
|
–
|
–
|
–
|
|
|
11
|
State Street
Boston,
Massachusetts
|
$45.5M
|
+$2.98M
|
+59,396
|
+6%
|
|
|
12
|
ArrowMark Colorado Holdings
Denver,
Colorado
|
$44.1M
|
+$16M
|
+319,223
|
+44%
|
|
|
13
|
Geode Capital Management
Boston,
Massachusetts
|
$34.6M
|
-$214K
|
-4,258
|
-0.5%
|
|
|
14
|
Aquilo Capital Management
San Francisco,
California
|
$32.5M
|
+$3.84M
|
+76,498
|
+11%
|
|
|
15
|
American Century Companies
Kansas City,
Missouri
|
$31M
|
+$5.97M
|
+118,993
|
+19%
|
|
|
16
|
Gilder Gagnon Howe & Co
New York
|
$30.3M
|
-$32.1M
|
-638,804
|
-47%
|
|
|
17
|
|
$29.5M
|
+$5.65M
|
+112,586
|
+19%
|
|
|
18
|
|
$23.6M
|
-$2.7M
|
-53,722
|
-9%
|
|
|
19
|
Pictet Asset Management (Switzerland)
Geneva 73,
Switzerland
|
$23.1M
|
-$260K
|
-5,188
|
-0.9%
|
|
|
20
|
Paradigm Biocapital Advisors
New York
|
$21.8M
|
+$1.31M
|
+26,073
|
+5%
|
|
|
21
|
Candriam SCA
Strassen, Luxembourg,
Luxembourg
|
$20.9M
|
+$313K
|
+6,240
|
+1%
|
|
|
22
|
Northern Trust
Chicago,
Illinois
|
$18.4M
|
+$53K
|
+1,057
|
+0.2%
|
|
|
23
|
Point72 Asset Management
Stamford,
Connecticut
|
$17.3M
|
-$22.4M
|
-446,179
|
-52%
|
|
|
24
|
5AM Venture Management
San Francisco,
California
|
$16.8M
|
–
|
–
|
–
|
|
|
25
|
|
$16.3M
|
+$8.16M
|
+162,652
|
+72%
|
|
