|
1
|
EcoR1 Capital
San Francisco,
California
|
$277M
|
+$29.4M
|
+1,259,428
|
+23%
|
|
|
2
|
|
$220M
|
+$9.01M
|
+385,256
|
+8%
|
|
|
3
|
Vanguard Group
Malvern,
Pennsylvania
|
$200M
|
+$5.68M
|
+243,167
|
+5%
|
|
|
4
|
|
$173M
|
+$98.5M
|
+4,213,483
|
New
|
|
|
5
|
T. Rowe Price Associates
Baltimore,
Maryland
|
$158M
|
+$26.7M
|
+1,143,452
|
+43%
|
|
|
6
|
Avidity Partners Management
Dallas,
Texas
|
$123M
|
+$8.65M
|
+370,157
|
+14%
|
|
|
7
|
Bellevue Group
Kuesnacht,
Switzerland
|
$103M
|
+$8.94M
|
+382,531
|
+18%
|
|
|
8
|
Citadel Advisors
Miami,
Florida
|
$99.3M
|
+$42.4M
|
+1,815,403
|
+291%
|
|
|
9
|
Fidelity Investments
Boston,
Massachusetts
|
$92.4M
|
-$61.3M
|
-2,624,276
|
-54%
|
|
|
10
|
|
$89.4M
|
+$4.29M
|
+183,582
|
+9%
|
|
|
11
|
Nextech Invest
Zurich,
Switzerland
|
$69.8M
|
+$32.9M
|
+1,408,394
|
+490%
|
|
|
12
|
ArrowMark Colorado Holdings
Denver,
Colorado
|
$64.6M
|
-$12.1M
|
-517,397
|
-25%
|
|
|
13
|
New Leaf Venture Partners
New York
|
$53.1M
|
–
|
–
|
–
|
|
|
14
|
State Street
Boston,
Massachusetts
|
$48.8M
|
+$632K
|
+27,022
|
+2%
|
|
|
15
|
Geode Capital Management
Boston,
Massachusetts
|
$46.2M
|
+$1.52M
|
+65,237
|
+6%
|
|
|
16
|
Commodore Capital
New York
|
$41.2M
|
+$23.4M
|
+1,000,000
|
New
|
|
|
17
|
Paradigm Biocapital Advisors
New York
|
$38.3M
|
+$21.8M
|
+931,303
|
New
|
|
|
18
|
|
$36.1M
|
+$8.7M
|
+372,246
|
+74%
|
|
|
19
|
Adage Capital Partners
Boston,
Massachusetts
|
$32.5M
|
+$18.5M
|
+789,485
|
New
|
|
|
20
|
Holocene Advisors
New York
|
$30.6M
|
+$17.4M
|
+744,465
|
New
|
|
|
21
|
|
$28.5M
|
+$6.76M
|
+289,157
|
+72%
|
|
|
22
|
|
$25.8M
|
+$14.7M
|
+627,788
|
New
|
|
|
23
|
Boxer Capital
San Diego,
California
|
$25.1M
|
+$14.2M
|
+608,614
|
New
|
|
|
24
|
Finepoint Capital
Boston,
Massachusetts
|
$20.8M
|
–
|
–
|
–
|
|
|
25
|
Dimensional Fund Advisors
Austin,
Texas
|
$20.2M
|
+$525K
|
+22,479
|
+5%
|
|
