|
1
|
Fidelity Investments
Boston,
Massachusetts
|
$298M
|
-$32.1M
|
-660,320
|
-9%
|
|
|
2
|
Avidity Partners Management
Dallas,
Texas
|
$193M
|
+$48M
|
+987,877
|
+29%
|
|
|
3
|
Vanguard Group
Malvern,
Pennsylvania
|
$186M
|
+$5.67M
|
+116,877
|
+3%
|
|
|
4
|
|
$165M
|
+$1.52M
|
+31,339
|
+0.9%
|
|
|
5
|
EcoR1 Capital
San Francisco,
California
|
$139M
|
–
|
–
|
–
|
|
|
6
|
Bellevue Group
Kuesnacht,
Switzerland
|
$97.5M
|
+$3.23M
|
+66,486
|
+3%
|
|
|
7
|
T. Rowe Price Associates
Baltimore,
Maryland
|
$97M
|
-$52.8M
|
-1,087,802
|
-33%
|
|
|
8
|
|
$93.1M
|
-$3.33M
|
-68,587
|
-3%
|
|
|
9
|
New Leaf Venture Partners
New York
|
$57.4M
|
–
|
–
|
–
|
|
|
10
|
T. Rowe Price Investment Management
Baltimore,
Maryland
|
$51.3M
|
+$56M
|
+1,153,576
|
New
|
|
|
11
|
State Street
Boston,
Massachusetts
|
$48.3M
|
+$268K
|
+5,512
|
+0.5%
|
|
|
12
|
ArrowMark Colorado Holdings
Denver,
Colorado
|
$42.4M
|
-$4.52M
|
-93,073
|
-9%
|
|
|
13
|
Geode Capital Management
Boston,
Massachusetts
|
$39.3M
|
+$3.06M
|
+62,993
|
+8%
|
|
|
14
|
American Century Companies
Kansas City,
Missouri
|
$34.6M
|
+$1.95M
|
+40,259
|
+5%
|
|
|
15
|
|
$34M
|
+$9.91M
|
+204,045
|
+36%
|
|
|
16
|
|
$32.6M
|
+$1.53M
|
+31,600
|
+5%
|
|
|
17
|
Wellington Management Group
Boston,
Massachusetts
|
$30.8M
|
-$36M
|
-742,300
|
-52%
|
|
|
18
|
Gilder Gagnon Howe & Co
New York
|
$30.3M
|
-$1.91M
|
-39,274
|
-5%
|
|
|
19
|
Aquilo Capital Management
San Francisco,
California
|
$29.9M
|
-$4.85M
|
-100,000
|
-13%
|
|
|
20
|
|
$26.2M
|
+$10.4M
|
+213,476
|
+57%
|
|
|
21
|
Candriam SCA
Strassen, Luxembourg,
Luxembourg
|
$23.1M
|
+$1.08M
|
+22,345
|
+4%
|
|
|
22
|
Pictet Asset Management (Switzerland)
Geneva 73,
Switzerland
|
$22.2M
|
-$2.42M
|
-49,764
|
-9%
|
|
|
23
|
Northern Trust
Chicago,
Illinois
|
$19.6M
|
+$129K
|
+2,650
|
+0.6%
|
|
|
24
|
Brown Advisory
Baltimore,
Maryland
|
$18.1M
|
+$5.17M
|
+106,497
|
+35%
|
|
|
25
|
5AM Venture Management
San Francisco,
California
|
$17.8M
|
–
|
–
|
–
|
|
