|
1
|
Fidelity Investments
Boston,
Massachusetts
|
$432M
|
+$21M
|
+608,854
|
+14%
|
|
|
2
|
RA Capital Management
Boston,
Massachusetts
|
$312M
|
–
|
–
|
–
|
|
|
3
|
Canaan Partners IX
Menlo Park,
California
|
$305M
|
-$13.8M
|
-400,000
|
-10%
|
|
|
4
|
|
$239M
|
+$17.1M
|
+497,210
|
+21%
|
|
|
5
|
New Leaf Venture Partners
New York
|
$194M
|
–
|
–
|
–
|
|
|
6
|
T. Rowe Price Associates
Baltimore,
Maryland
|
$191M
|
+$48.5M
|
+1,405,654
|
+167%
|
|
|
7
|
Bellevue Group
Kuesnacht,
Switzerland
|
$186M
|
+$19M
|
+550,000
|
+34%
|
|
|
8
|
|
$152M
|
+$61.8M
|
+1,790,996
|
New
|
|
|
9
|
Avidity Partners Management
Dallas,
Texas
|
$152M
|
+$15.1M
|
+439,058
|
+33%
|
|
|
10
|
Gilder Gagnon Howe & Co
New York
|
$149M
|
+$14.9M
|
+430,862
|
+33%
|
|
|
11
|
Vanguard Group
Malvern,
Pennsylvania
|
$148M
|
+$17.1M
|
+494,711
|
+40%
|
|
|
12
|
|
$137M
|
+$15.8M
|
+458,362
|
+40%
|
|
|
13
|
Marshall Wace
London,
United Kingdom
|
$73.3M
|
+$26.4M
|
+766,932
|
+797%
|
|
|
14
|
State Street
Boston,
Massachusetts
|
$65.1M
|
+$3.57M
|
+103,612
|
+16%
|
|
|
15
|
Rock Springs Capital Management
Baltimore,
Maryland
|
$63.4M
|
+$9.12M
|
+264,532
|
+55%
|
|
|
16
|
Marshall Wace North America
New York
|
$52.6M
|
+$18.3M
|
+531,045
|
+598%
|
|
|
17
|
ArrowMark Colorado Holdings
Denver,
Colorado
|
$49M
|
+$8.55M
|
+247,880
|
+75%
|
|
|
18
|
Sectoral Asset Management
Montreal,
Quebec, Canada
|
$45.2M
|
-$5.84M
|
-169,387
|
-24%
|
|
|
19
|
Geode Capital Management
Boston,
Massachusetts
|
$43.8M
|
+$4.29M
|
+124,465
|
+32%
|
|
|
20
|
5AM Venture Management
San Francisco,
California
|
$42.5M
|
-$17.2M
|
-500,000
|
-50%
|
|
|
21
|
Point72 Asset Management
Stamford,
Connecticut
|
$42.5M
|
+$15.1M
|
+436,675
|
+690%
|
|
|
22
|
|
$42.1M
|
+$3.16M
|
+91,544
|
+23%
|
|
|
23
|
American Century Companies
Kansas City,
Missouri
|
$38.5M
|
+$8.37M
|
+242,790
|
+116%
|
|
|
24
|
Consonance Capital Management
New York
|
$36.1M
|
+$14.7M
|
+425,000
|
New
|
|
|
25
|
Northern Trust
Chicago,
Illinois
|
$33.3M
|
+$2.04M
|
+59,046
|
+18%
|
|
