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Baker Bros. Advisors Portfolio holdings

AUM $17.4B
1-Year Est. Return 131.5%
This Fund
S&P 500
This Quarter Est. Return
+23.73%
1 Year Est. Return
+131.5%
3 Year Est. Return
+336.81%
5 Year Est. Return
+553.16%
10 Year Est. Return
+4,134.93%
AUM
$8.79B
AUM Growth
-$8.56B
Cap. Flow
-$9.86B
Cap. Flow %
-112.21%
Top 10 Hldgs %
80.97%
Holding
105
New
4
Increased
25
Reduced
11
Closed
21

Top Buys

Rank Stock Value
1
MRTX
Mirati Therapeutics, Inc. Common Stock
MRTX
+$152M
2
MDGL icon
Madrigal Pharmaceuticals
MDGL
+$74.3M
3
RVMD icon
Revolution Medicines
RVMD
+$59M
4
REPL icon
Replimune Group
REPL
+$57.6M
5
CERE
Cerevel Therapeutics Holdings, Inc. Common Stock
CERE
+$46M

Top Sells

Rank Stock Value
1
SGEN
Seagen Inc. Common Stock
SGEN
+$9.45B
2
BMRN icon
BioMarin Pharmaceuticals
BMRN
+$337M
3
ONC
BeOne Medicines Ltd
ONC
+$199M
4
SWTX
SpringWorks Therapeutics
SWTX
+$69.4M
5
ROIV icon
Roivant Sciences
ROIV
+$41.8M

Sector Composition

Rank Sector Weight
1 Healthcare 98.37%
2 Financials 0.06%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
PNT
101
DELISTED
POINT Biopharma Global Inc. Common Stock
PNT
– –
-249,968
Closed -$1.67M
SGEN
102
DELISTED
Seagen Inc. Common Stock
SGEN
– –
-44,554,162
Closed -$9.45B
GTH
103
DELISTED
Genetron Holdings Limited ADS
GTH
– –
-151,769
Closed -$370K
1 2 3 4
5

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CM
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MCM
MAI Capital Management Independence, Ohio $17.7B AUM 18.87% 1-Year Est. Return
ASRS
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PP
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VMPIC
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LA
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BCIM
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Baker Bros. Advisors's Q4 2023 Portfolio in Review

As of Q4 2023, Baker Bros. Advisors held 105 positions worth $8.79B, down 49% from $17.4B the previous quarter. Its ten largest holdings account for 81% of the portfolio.

Baker Bros. Advisors withdrew a net $9.86B in Q4 2023, closing 21 positions and reducing 11 holdings. Its most notable exit was Seagen Inc. Common Stock, an estimated $9.45B position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 98% of assets, down from 99% a quarter earlier, followed by Financials.

Against the trend, Baker Bros. Advisors opened a new position in Cerevel Therapeutics Holdings, Inc. Common Stock worth $67.8M.

  • Baker Bros. Advisors's largest Q4 2023 buy was Cerevel Therapeutics Holdings, Inc. Common Stock: 1,600,000 shares worth $67.8M.
  • Baker Bros. Advisors added most to Mirati Therapeutics, Inc. Common Stock in Q4 2023, an estimated $152M increase.
  • Baker Bros. Advisors's biggest Q4 2023 reduction was BeOne Medicines Ltd, cutting an estimated $199M.
  • Baker Bros. Advisors fully exited Seagen Inc. Common Stock in Q4 2023, selling an estimated $9.45B.
  • Baker Bros. Advisors's ten largest holdings make up 81% of its $8.79B portfolio in Q4 2023.
  • Baker Bros. Advisors opened 4 new positions and closed 21 in Q4 2023.
  • Baker Bros. Advisors's portfolio value fell 49% quarter-over-quarter to $8.79B.

Based on Baker Bros. Advisors's 13F filing for Q4 2023, filed 14 Feb 2024.